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aspn asporin (LRR class 1) [ Danio rerio (zebrafish) ]

Gene ID: 65228, updated on 12-Sep-2024

Summary

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Official Symbol
aspnprovided by ZNC
Official Full Name
asporin (LRR class 1)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041105-7
See related
Ensembl:ENSDARG00000002192 AllianceGenome:ZFIN:ZDB-GENE-041105-7
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bgl3; aspnl; wu:fk08c11; zgc:109936
Summary
Predicted to enable calcium ion binding activity and collagen binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in axial vasculature; chondrocranium; and pharyngeal arch. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See aspn in Genome Data Viewer
Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10479965..10487511, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10450283..10457829, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteoglycin, paralog a Neighboring gene osteomodulin Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Biglycan-like extracellular matrix genes of agnathans and teleosts. Shintani S, et al. J Mol Evol, 2000 Oct. PMID 11040287
  2. Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Liu H, et al. Environ Pollut, 2019 Mar. PMID 30579210
  3. A switch in pdgfrb(+) cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Tsata V, et al. Dev Cell, 2021 Feb 22. PMID 33412105
  4. Screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Padhi BK, et al. Dev Dyn, 2004 Nov. PMID 15376328
  5. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
asporin
Names
biglycan-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131713.2 → NP_571788.2  asporin precursor

    Status: VALIDATED

    Source sequence(s)
    BC078368, EE689153, EE697401
    UniProtKB/TrEMBL
    A0A8M1P6K1, Q1LXA7
    Related
    ENSDARP00000064797.5, ENSDART00000064798.6
    Conserved Domains (4) summary
    smart00013
    Location:64 → 94
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:133 → 323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:74 → 93
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:97 → 152
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    10479965..10487511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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