ripply1 ripply transcriptional repressor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ripply1provided by ZNC
Official Full Name: ripply transcriptional repressor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060113-1
See related: Ensembl:ENSDARG00000054103 AllianceGenome:ZFIN:ZDB-GENE-060113-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Involved in negative regulation of DNA-templated transcription and somite rostral/caudal axis specification. Acts upstream of or within regulation of skeletal muscle tissue development and somite specification. Located in nucleus. Is expressed in several structures, including margin; paraxial mesoderm; presumptive paraxial mesoderm; shield; and somite. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 6. Orthologous to several human genes including RIPPLY2 (ripply transcriptional repressor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (37967457..37972497, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (37919751..37924791, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We further showed that somite boundaries that were recovered in tbx6(+/-); ripply1(-/-) embryos were dependent on the function of ripply2, indicating that relative gene dosage between ripply1/2 and tbx6 plays a critical role in the somite formation.
Title: Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish.
Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.
Title: Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.
difference in anteroposterior elongagion is attributable to spatiotemporal inhibition of the clock gene her1 via retinoic acid regulation of the transcriptional repressor ripply1.
Title: Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anteroposterior somitogenetic rate difference.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somite rostral/caudal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein ripply1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.