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LRRC61 leucine rich repeat containing 61 [ Homo sapiens (human) ]

Gene ID: 65999, updated on 5-Mar-2024

Summary

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Official Symbol
LRRC61provided by HGNC
Official Full Name
leucine rich repeat containing 61provided by HGNC
Primary source
HGNC:HGNC:21704
See related
Ensembl:ENSG00000127399 AllianceGenome:HGNC:21704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC295
Summary
Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 5.1), adrenal (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

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See LRRC61 in Genome Data Viewer
Location:
7q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150309499..150338156)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151487758..151516408)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150006588..150035245)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin related protein 3C Neighboring gene uncharacterized LOC124901772 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:149697909-149698096 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149721691-149722215 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149728774-149729275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149732655-149733170 Neighboring gene uncharacterized LOC100134040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149745856-149746490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149746491-149747124 Neighboring gene Sharpr-MPRA regulatory region 3139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917438-149917972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917973-149918507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149966003-149966503 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149976749-149977333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149983589-149984090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149984091-149984590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26822 Neighboring gene Sharpr-MPRA regulatory region 1750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18774 Neighboring gene uncharacterized LOC107986858 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:150044724-150044956 Neighboring gene zinc finger BED-type containing 10, pseudogene Neighboring gene retinoic acid receptor responder 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article
  2. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  3. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
  4. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, et al. Mol Cell, 2021 Jun 17. PMID 33957083
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3036, FLJ22216, FLJ31392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142928.2 → NP_001136400.1  leucine-rich repeat-containing protein 61

    See identical proteins and their annotated locations for NP_001136400.1

    Status: VALIDATED

    Source sequence(s)
    AC005586, AW444958
    Consensus CDS
    CCDS5901.1
    UniProtKB/Swiss-Prot
    B3KUW0, D3DWY8, Q9BV99
    UniProtKB/TrEMBL
    A0A090N7W5, B3KSM2
    Related
    ENSP00000352642.4, ENST00000359623.9
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:58 → 165
    LRR_9; Leucine-rich repeat

  2. NM_001363433.1 → NP_001350362.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    BG758667, BM126106, BM455442, DA936889, DA949948, HY253453
    Consensus CDS
    CCDS5901.1
    UniProtKB/Swiss-Prot
    B3KUW0, D3DWY8, Q9BV99
    UniProtKB/TrEMBL
    A0A090N7W5, B3KSM2
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:58 → 165
    LRR_9; Leucine-rich repeat

  3. NM_001363434.1 → NP_001350363.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC005586, AK098061, BM126106
    Consensus CDS
    CCDS5901.1
    UniProtKB/Swiss-Prot
    B3KUW0, D3DWY8, Q9BV99
    UniProtKB/TrEMBL
    A0A090N7W5, B3KSM2
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:58 → 165
    LRR_9; Leucine-rich repeat

  4. NM_023942.3 → NP_076431.1  leucine-rich repeat-containing protein 61

    See identical proteins and their annotated locations for NP_076431.1

    Status: VALIDATED

    Source sequence(s)
    AC005586, AW444958
    Consensus CDS
    CCDS5901.1
    UniProtKB/Swiss-Prot
    B3KUW0, D3DWY8, Q9BV99
    UniProtKB/TrEMBL
    A0A090N7W5, B3KSM2
    Related
    ENSP00000339047.6, ENST00000323078.7
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:58 → 165
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150309499..150338156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151487758..151516408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BV99.1 GenPept UniProtKB/Swiss-Prot:Q9BV99

Gene LinkOut

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