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STATH statherin [ Homo sapiens (human) ]

Gene ID: 6779, updated on 2-Nov-2024

Summary

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Official Symbol
STATHprovided by HGNC
Official Full Name
statherinprovided by HGNC
Primary source
HGNC:HGNC:11369
See related
Ensembl:ENSG00000126549 MIM:184470; AllianceGenome:HGNC:11369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STR
Summary
Predicted to enable hydroxyapatite binding activity. Predicted to be involved in ossification. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward salivary gland (RPKM 34203.8) See more
Orthologs
all
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Genomic context

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See STATH in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69995966..70002570)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73330761..73337367)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70861683..70868287)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene casein beta Neighboring gene uncharacterized LOC105377269 Neighboring gene histatin 3 Neighboring gene histatin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A statherin and calcium enriched layer at the air interface of human parotid saliva. Proctor GB, et al. Biochem J, 2005 Jul 1. PMID 15769251, Free PMC Article
  2. Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva. Schlesinger DH, et al. J Biol Chem, 1977 Mar 10. PMID 838735
  3. Salivary statherin. Dependence on sequence, charge, hydrogen bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization. Raj PA, et al. J Biol Chem, 1992 Mar 25. PMID 1313424
  4. Structure and sequence determination of the gene encoding human salivary statherin. Sabatini LM, et al. Gene, 1990 May 14. PMID 2373369
  5. Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques. Sabatini LM, et al. J Dent Res, 1989 Jul. PMID 2483725

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis.
    Title: Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis.
  2. A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis.
    Title: A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis.
  3. The total protein and statherin in the in-vivo AEP were different between eroded and non-eroded tooth surfaces of the same patient
    Title: Reduced statherin in acquired enamel pellicle on eroded teeth compared to healthy teeth in the same subjects: An in-vivo study.
  4. effects of statherin on intracellular calcium level and its subsequent related molecular alterations would give us new pathogenic aspect in oral carcinogenesis
    Title: Role of statherin in oral carcinogenesis.
  5. phenylalanine orientations in statherin bound to hydroxyapatite surfaces
    Title: Direct observation of phenylalanine orientations in statherin bound to hydroxyapatite surfaces.
  6. Data show that the full characterization of the statherin peptides generated facilitates the elucidation of their novel functional roles in the oral and gastro-intestinal environment.
    Title: Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  8. insight into the molecular interactions of statherin with hydroxyapatite surfaces
    Title: A (13)C{(31)P} REDOR NMR investigation of the role of glutamic acid residues in statherin- hydroxyapatite recognition.
  9. In conclusion, statherin induces transition to yeast of Candida albicans hyphae and may thus contribute to the oral defense against candidiasis.
    Title: Identification of salivary components that induce transition of hyphae to yeast in Candida albicans.
  10. inhibits calcium phosphate precipitation
    Title: Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of statherin (STATH) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: HTN3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix constituent, lubricant activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables hydroxyapatite binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of tooth enamel NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of bone mineralization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ossification TAS
Traceable Author Statement
more info
 PubMed 
involved_in saliva secretion NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
statherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009181.2 → NP_001009181.1  statherin isoform b precursor

    See identical proteins and their annotated locations for NP_001009181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AC063956, BC067219, CB958641, CB986973
    Consensus CDS
    CCDS33998.1
    UniProtKB/Swiss-Prot
    P02808
    Related
    ENSP00000370448.2, ENST00000381060.2

  2. NM_003154.3 → NP_003145.1  statherin isoform a precursor

    See identical proteins and their annotated locations for NP_003145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC063956, BC067219, CB958641, CB986973
    Consensus CDS
    CCDS3533.1
    UniProtKB/Swiss-Prot
    A6NKE9, B2R4F8, P02808
    Related
    ENSP00000246895.4, ENST00000246895.9
    Conserved Domains (1) summary
    pfam03875
    Location:20 → 50
    Statherin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    69995966..70002570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171801.1 Reference GRCh38.p14 PATCHES

    Range
    36102..42706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    73330761..73337367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02808.2 GenPept UniProtKB/Swiss-Prot:P02808

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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