vegfd vascular endothelial growth factor D [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vegfdprovided by ZNC
Official Full Name: vascular endothelial growth factor Dprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070810-6
See related: Ensembl:ENSDARG00000056624 AllianceGenome:ZFIN:ZDB-GENE-070810-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: figf; vegf-d
Summary: Predicted to enable chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within with a positive effect on lymph vessel development. Acts upstream of or within angiogenesis; blood circulation; and lymphangiogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including pectoral fin; pectoral fin bud; post-vent region; spinal cord; and tail bud. Orthologous to human VEGFD (vascular endothelial growth factor D). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (29906805..29917122, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (29659211..29670156, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries.
Title: Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries.
vegfc and vegfd cooperatively control lymphangiogenesis throughout the embryo, including during the formation of the trunk lymphatic vasculature. Interestingly, we find that vegfd and vegfc also redundantly drive artery hyperbranching phenotypes observed upon depletion of Flt1 or Dll4.
Title: Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development.
Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting.
Title: Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting.
VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks.
Title: VEGFD regulates blood vascular development by modulating SOX18 activity.
Our studies therefore identified the first non-mammalian VEGF-D and established its in vivo role for vascular system development during vertebrate embryogenesis and provided an alternative animal model to further reveal functions of VEGF-D.
Title: A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymph vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect lymph vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular endothelial growth factor D

Names: c-fos induced growth factor; vascular enthelial growth factor D; vegf d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.