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Poglut3 protein O-glucosyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 68304, updated on 28-Oct-2024

Summary

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Official Symbol
Poglut3provided by MGI
Official Full Name
protein O-glucosyltransferase 3provided by MGI
Primary source
MGI:MGI:1923765
See related
Ensembl:ENSMUSG00000034487 AllianceGenome:MGI:1923765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kdelc2; 2010004J24Rik; 4833410J10Rik
Summary
Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Is expressed in liver and white fat. Orthologous to human POGLUT3 (protein O-glucosyltransferase 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 6.7), bladder adult (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Poglut3 in Genome Data Viewer
Location:
9 A5.3; 9 29.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53294217..53313167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53383004..53401867)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 10 Neighboring gene STARR-positive B cell enhancer ABC_E1786 Neighboring gene STARR-seq mESC enhancer starr_24140 Neighboring gene exophilin 5 Neighboring gene STARR-seq mESC enhancer starr_24141 Neighboring gene RIKEN cDNA 4930550C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53213128-53213311 Neighboring gene microRNA 130c Neighboring gene ataxia telangiectasia mutated Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53344652-53344897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Takeuchi H, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21949356, Free PMC Article
  2. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, et al. Development, 2011 May. PMID 21490058, Free PMC Article
  3. Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues. Neupane S, et al. J Biol Chem, 2024 Jul. PMID 38844137, Free PMC Article
  4. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.
    Title: Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables EGF-domain serine glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables EGF-domain serine xylosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables UDP-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-xylosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via serine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-glucosyltransferase 3
Names
KDEL (Lys-Asp-Glu-Leu) containing 2
KDEL motif-containing protein 2
protein O-xylosyltransferase POGLUT3
NP_997610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212445.2 → NP_997610.1  protein O-glucosyltransferase 3 precursor

    See identical proteins and their annotated locations for NP_997610.1

    Status: VALIDATED

    Source sequence(s)
    AC079869, AK019513, AK020078, AK075811, AK076412
    Consensus CDS
    CCDS23182.1
    UniProtKB/Swiss-Prot
    G5E897, Q8C6F3
    Related
    ENSMUSP00000039313.4, ENSMUST00000037853.5
    Conserved Domains (3) summary
    smart00557
    Location:24 → 128
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:22 → 126
    Filamin; Filamin/ABP280 repeat
    cl23835
    Location:147 → 481
    Glyco_transf_90; Glycosyl transferase family 90

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    53294217..53313167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004935541.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E897.1 GenPept UniProtKB/Swiss-Prot:G5E897

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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