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Ift25 intraflagellar transport 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685284, updated on 18-Sep-2024

Summary

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Official Symbol
Ift25provided by RGD
Official Full Name
intraflagellar transport 25provided by RGD
Primary source
RGD:1596413
See related
EnsemblRapid:ENSRNOG00000010241 AllianceGenome:RGD:1596413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hspb11
Summary
Predicted to be involved in kidney development; smoothened signaling pathway; and spermatogenesis. Predicted to act upstream of or within animal organ development; left/right axis specification; and skeletal system development. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Orthologous to human HSPB11 (heat shock protein family B (small) member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 73.1), Lung (RPKM 58.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift25 in Genome Data Viewer
Location:
5q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127264450..127291225)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122035588..122062421)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126856128..126882913)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene transmembrane protein 59 Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene iodothyronine deiodinase 1 Neighboring gene uncharacterized LOC134486960

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation. Liu H, et al. Biol Reprod, 2017 May 1. PMID 28430876, Free PMC Article
  2. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Desai PB, et al. Mech Dev, 2018 Jun. PMID 29626631, Free PMC Article
  3. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Keady BT, et al. Dev Cell, 2012 May 15. PMID 22595669, Free PMC Article
  4. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Ishikawa H, et al. Elife, 2014 Jan 1. PMID 24596149, Free PMC Article
  5. Characterization of mouse IFT complex B. Follit JA, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19253336, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC187878

Gene Ontology Provided by RGD

Process Evidence Code Pubs
NOT involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within left/right axis specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 25 homolog
Names
Hspb11 heat shock protein family B (small), member 11
heat shock protein beta-11
heat shock protein family B (small), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131002.1 → NP_001124474.1  intraflagellar transport protein 25 homolog

    See identical proteins and their annotated locations for NP_001124474.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162011
    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467
    Conserved Domains (1) summary
    pfam00754
    Location:19 → 125
    F5_F8_type_C; F5/8 type C domain

  2. NM_001429184.1 → NP_001416113.1  intraflagellar transport protein 25 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467

  3. NM_001429185.1 → NP_001416114.1  intraflagellar transport protein 25 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467

  4. NM_001429186.1 → NP_001416115.1  intraflagellar transport protein 25 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    127264450..127291225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763899.4 → XP_008762121.1  intraflagellar transport protein 25 homolog isoform X3

    See identical proteins and their annotated locations for XP_008762121.1

    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467
    Conserved Domains (1) summary
    pfam00754
    Location:19 → 125
    F5_F8_type_C; F5/8 type C domain

  2. XM_006238524.5 → XP_006238586.3  intraflagellar transport protein 25 homolog isoform X1

    Related
    ENSRNOP00000054174.4, ENSRNOT00000057362.6

  3. XM_063288427.1 → XP_063144497.1  intraflagellar transport protein 25 homolog isoform X4

  4. XM_006238530.4 → XP_006238592.1  intraflagellar transport protein 25 homolog isoform X3

    Conserved Domains (1) summary
    pfam00754
    Location:19 → 125
    F5_F8_type_C; F5/8 type C domain

  5. XM_039110786.2 → XP_038966714.1  intraflagellar transport protein 25 homolog isoform X3

    Conserved Domains (1) summary
    pfam00754
    Location:19 → 125
    F5_F8_type_C; F5/8 type C domain

  6. XM_039110787.2 → XP_038966715.1  intraflagellar transport protein 25 homolog isoform X3

    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467
    Conserved Domains (1) summary
    pfam00754
    Location:19 → 125
    F5_F8_type_C; F5/8 type C domain

  7. XM_017593635.3 → XP_017449124.1  intraflagellar transport protein 25 homolog isoform X3

    UniProtKB/TrEMBL
    A0A9K3Y7X2, B1WC57, D4A467
    Conserved Domains (1) summary
    pfam00754
    Location:19 → 125
    F5_F8_type_C; F5/8 type C domain

  8. XM_063288426.1 → XP_063144496.1  intraflagellar transport protein 25 homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2K664
    Related
    ENSRNOP00000073693.1, ENSRNOT00000080701.3

  9. XM_017593632.3 → XP_017449121.1  intraflagellar transport protein 25 homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2K664
    Conserved Domains (1) summary
    pfam00754
    Location:29 → 135
    F5_F8_type_C; F5/8 type C domain
Nucleotide Protein Strain
Heading Accession and Version

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