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Kmt5a lysine methyltransferase 5A [ Rattus norvegicus (Norway rat) ]

Gene ID: 689820, updated on 17-Jun-2024

Summary

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Official Symbol
Kmt5aprovided by RGD
Official Full Name
lysine methyltransferase 5Aprovided by RGD
Primary source
RGD:1587560
See related
Ensembl:ENSRNOG00000064318 AllianceGenome:RGD:1587560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Setd8; Pr-set7; RGD1305893
Summary
Predicted to enable histone-lysine N-methyltransferase activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be located in cytosol and nucleoplasm. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 143.0), Adrenal (RPKM 141.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kmt5a in Genome Data Viewer
Location:
12q15
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37800339..37823706, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32139353..32167777, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37558150..37581183, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 35 Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene strawberry notch homolog 1 Neighboring gene cyclin-dependent kinase 2 associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury. Li X, et al. Mediators Inflamm, 2023. PMID 36936537, Free PMC Article
  2. Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat. Barrett E, et al. Reprod Sci, 2021 May. PMID 33398850, Free PMC Article
  3. Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration. Pan C, et al. PLoS One, 2012. PMID 22720056, Free PMC Article
  4. Targeting protein lysine methylation and demethylation in cancers. He Y, et al. Acta Biochim Biophys Sin (Shanghai), 2012 Jan. PMID 22194015, Free PMC Article
  5. Modulation of p53 function by SET8-mediated methylation at lysine 382. Shi X, et al. Mol Cell, 2007 Aug 17. PMID 17707234, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/beta-Catenin Signaling Pathway.
    Title: Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/β-Catenin Signaling Pathway.
  2. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
    Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
  3. Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.
    Title: Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.
  4. Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARgamma-KMT5A Axis in the Rat.
    Title: Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H4K20 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K20 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K20 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in polytene chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-lysine methyltransferase KMT5A
Names
N-lysine methyltransferase SETD8
SET domain containing (lysine methyltransferase) 8
SET domain-containing 8
histone methyltransferase Pr-set7/Set8
histone-lysine N-methyltransferase SETD8
lysine (K)-specific methyltransferase 5A
NP_001233594.2
NP_001400566.1
XP_006249390.1
XP_006249392.1
XP_017453947.1
XP_038945699.1
XP_038945701.1
XP_063127745.1
XP_063127746.1
XP_063127747.1
XP_063127749.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001246665.2 → NP_001233594.2  N-lysine methyltransferase KMT5A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5ZY89, A0A8J8XFN9
    Related
    ENSRNOP00000084143.1, ENSRNOT00000106166.1

  2. NM_001413637.1 → NP_001400566.1  N-lysine methyltransferase KMT5A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A5Q1, A0A8I6GKG3
    Related
    ENSRNOP00000092997.1, ENSRNOT00000108981.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    37800339..37823706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249328.4 → XP_006249390.1  N-lysine methyltransferase KMT5A isoform X3

    UniProtKB/TrEMBL
    A0A8J8XFN9
    Conserved Domains (1) summary
    smart00317
    Location:222 → 339
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  2. XM_063271679.1 → XP_063127749.1  N-lysine methyltransferase KMT5A isoform X7

    UniProtKB/TrEMBL
    A6J0Z8

  3. XM_017598458.3 → XP_017453947.1  N-lysine methyltransferase KMT5A isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZQS7, A6J0Z8
    Related
    ENSRNOP00000080894.1
    Conserved Domains (1) summary
    cd10528
    Location:143 → 282
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

  4. XM_039089771.2 → XP_038945699.1  N-lysine methyltransferase KMT5A isoform X4

    UniProtKB/TrEMBL
    A0A8J8XFN9, D3ZEB9, F7J138
    Related
    ENSRNOP00000062763.3
    Conserved Domains (1) summary
    cd10528
    Location:197 → 336
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

  5. XM_063271675.1 → XP_063127745.1  N-lysine methyltransferase KMT5A isoform X1

    UniProtKB/TrEMBL
    A0A8J8XFN9

  6. XM_039089773.2 → XP_038945701.1  N-lysine methyltransferase KMT5A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZY89, A0A8J8XFN9
    Conserved Domains (1) summary
    cd10528
    Location:192 → 331
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

  7. XM_063271677.1 → XP_063127747.1  N-lysine methyltransferase KMT5A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZY89, A0A8J8XFN9

  8. XM_063271676.1 → XP_063127746.1  N-lysine methyltransferase KMT5A isoform X2

    UniProtKB/TrEMBL
    A0A8J8XFN9

  9. XM_006249330.4 → XP_006249392.1  N-lysine methyltransferase KMT5A isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZQS7, A6J0Z8
    Conserved Domains (1) summary
    cd10528
    Location:143 → 282
    SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins

RNA

  1. XR_010056419.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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