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dsx transcription factor doublesex [ Bombyx mori (domestic silkworm) ]

Gene ID: 692415, updated on 12-Oct-2024

Summary

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Gene symbol
dsx
Gene description
transcription factor doublesex
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bombyx mori
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
Also known as
dsx1; dsx2; dsx3; dsx4; dsx5; Bmdsx; dsxf1; dsxf2; dsxf3; dsxf4; dsxf5; dsxf6; dsxf7; dsxf8; dsxf9; dsxm1; dsxm2; dsxm3; dsxm4; dsxm5; dsxm6; dsxm7; dsxf10; dsx-dsr3; dsx-dsr4; dsx-dsr5; dsx-dsr7
Orthologs
fruit fly all
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Genomic context

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See dsx in Genome Data Viewer
Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 25 NC_085131.1 (10593002..10796765, complement)
103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 25 NC_051382.1 (10580656..10778265, complement)

Chromosome 25 - NC_085131.1Genomic Context describing neighboring genes Neighboring gene homeobox protein prospero Neighboring gene uncharacterized LOC134201433 Neighboring gene Uxt prefoldin-like subunit Neighboring gene pickpocket protein 28 Neighboring gene NAD-dependent deacetylase sirtuin 2 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenic Expression of the piRNA-Resistant Masculinizer Gene Induces Female-Specific Lethality and Partial Female-to-Male Sex Reversal in the Silkworm, Bombyx mori. Sakai H, et al. PLoS Genet, 2016 Aug. PMID 27579676, Free PMC Article
  2. The mechanism of sex-specific splicing at the doublesex gene is different between Drosophila melanogaster and Bombyx mori. Suzuki MG, et al. Insect Biochem Mol Biol, 2001 Nov 1. PMID 11583933
  3. Novel female-specific splice form of dsx in the silkworm, Bombyx mori. Shukla JN, et al. Genetica, 2011 Jan. PMID 20714790
  4. Novel female-specific trans-spliced and alternative splice forms of dsx in the silkworm Bombyx mori. Duan J, et al. Biochem Biophys Res Commun, 2013 Feb 15. PMID 23261436
  5. New insights into the genomic organization and splicing of the doublesex gene, a terminal regulator of sexual differentiation in the silkworm Bombyx mori. Duan J, et al. PLoS One, 2013. PMID 24244545, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fatty Acid Desaturase Bmdesat5, Suppressed in the Salivary Glands by Domestication, is Involved in Regulation of Food Intake in Silkworms.
    Title: Fatty Acid Desaturase Bmdesat5, Suppressed in the Salivary Glands by Domestication, is Involved in Regulation of Food Intake in Silkworms.
  2. Role of small nucleolar RNAs in alternative splicing of the doublesex gene in the silkworm, Bombyx mori.
    Title: Role of small nucleolar RNAs in alternative splicing of the doublesex gene in the silkworm, Bombyx mori.
  3. Transgenic and knockout analyses of Masculinizer and doublesex illuminated the unique functions of doublesex in germ cell sexual development of the silkworm, Bombyx mori.
    Title: Transgenic and knockout analyses of Masculinizer and doublesex illuminated the unique functions of doublesex in germ cell sexual development of the silkworm, Bombyx mori.
  4. Identification and characterization of sexually dimorphic neurons that express the sex-determining gene doublesex in the brain of silkmoth Bombyx mori.
    Title: Identification and characterization of sexually dimorphic neurons that express the sex-determining gene doublesex in the brain of silkmoth Bombyx mori.
  5. Results suggest that the antisense lncRNA Bmdsx-AS1 was involved in alternative splicing of Bmdsx in the silkworm.
    Title: An antisense lncRNA functions in alternative splicing of Bmdsx in the silkworm, Bombyx mori.
  6. knockdown of EPPase and one isoform of EcR (EcR-A) resulted in decreased expression of Bombyx doublesex (Bmdsx), a master regulatory gene for sexual differentiation of the silkworm in both male and female embryos.
    Title: Involvement of Ecdysone Signaling in the Expression of the doublesex Gene during Embryonic Development in the Silkworm, Bombyx mori.
  7. A new regulatory mechanism of doublesex alternative splicing in the silkworm.
    Title: Alternative splicing regulation of doublesex gene by RNA-binding proteins in the silkworm Bombyx mori.
  8. C-terminus of DSX(F5) splice form functioned as a regulatory domain during regulation of downstream target gene expression and the sexual development of somatic cells .
    Title: The C-terminus of DSX(F5) protein acts as a novel regulatory domain in Bombyx mori.
  9. Disruptions of dsx gene function produced either male-specific sexually-dimorphic defects or intersexual phenotypes; these results differ from those observed in other insects, including Drosophila melanogaster.
    Title: Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex.
  10. One of the Masc-R strains weakly expressed Masc-R in various tissues. Females heterozygous for the transgene expressed male-specific isoform of the Bombyx homolog of insulin-like growth factor II mRNA-binding protein (ImpM) and Bmdsx
    Title: Transgenic Expression of the piRNA-Resistant Masculinizer Gene Induces Female-Specific Lethality and Partial Female-to-Male Sex Reversal in the Silkworm, Bombyx mori.
Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
doublesex; transcription factor doublesex
Names
doublesex 5
doublesex F1
doublesex F2
doublesex F3
doublesex F5
doublesex M1
doublesex M3
nonfunctional doublesex 2
nonfunctional doublesex F4
nonfunctional doublesex M2
nonfunctional doublesex M4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043406.1 → NP_001036871.1  transcription factor doublesex isoform F

    See identical proteins and their annotated locations for NP_001036871.1

    Status: PROVISIONAL

    Source sequence(s)
    AB048543
    UniProtKB/TrEMBL
    Q9GV03, S5U9X4
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:171 → 230
    DSX_dimer; Doublesex dimerization domain

  2. NM_001111345.1 → NP_001104815.1  transcription factor doublesex isoform M

    See identical proteins and their annotated locations for NP_001104815.1

    Status: PROVISIONAL

    Source sequence(s)
    AB048544
    UniProtKB/TrEMBL
    Q9GR94, Q9GV02
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:171 → 227
    DSX_dimer; Doublesex dimerization domain

RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM3026992v2 Primary Assembly

Genomic

  1. NC_085131.1 Reference ASM3026992v2 Primary Assembly

    Range
    10593002..10796765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_062675972.1 → XP_062531956.1  doublesex isoform X4

    UniProtKB/TrEMBL
    S5U9Y1

  2. XM_012688769.4 → XP_012544223.1  doublesex isoform X6

    See identical proteins and their annotated locations for XP_012544223.1

    UniProtKB/TrEMBL
    Q9GR95, S5U9X4
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:171 → 230
    DSX_dimer; Doublesex dimerization domain

  3. XM_012688778.4 → XP_012544232.1  doublesex isoform X7

    See identical proteins and their annotated locations for XP_012544232.1

    UniProtKB/TrEMBL
    S5TJ21, S5U9X4
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:171 → 230
    DSX_dimer; Doublesex dimerization domain

  4. XM_012688749.4 → XP_012544203.1  doublesex isoform X1

    See identical proteins and their annotated locations for XP_012544203.1

    UniProtKB/TrEMBL
    S5TSF6, S5U957
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:198 → 254
    DSX_dimer; Doublesex dimerization domain

  5. XM_038020188.2 → XP_037876116.1  doublesex isoform X2

    UniProtKB/TrEMBL
    A0A8R2M6Y2
    Conserved Domains (2) summary
    pfam08828
    Location:199 → 257
    DSX_dimer; Doublesex dimerization domain
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain

  6. XM_062675970.1 → XP_062531954.1  doublesex isoform X2

    UniProtKB/TrEMBL
    A0A8R2M6Y2

  7. XM_012688790.4 → XP_012544244.1  doublesex isoform X9

    See identical proteins and their annotated locations for XP_012544244.1

    UniProtKB/TrEMBL
    S5TJ17, S5U9X4
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:171 → 230
    DSX_dimer; Doublesex dimerization domain

  8. XM_012688757.4 → XP_012544211.1  doublesex isoform X5

    See identical proteins and their annotated locations for XP_012544211.1

    UniProtKB/TrEMBL
    S5TSE9, S5U9X4
    Conserved Domains (2) summary
    pfam00751
    Location:32 → 77
    DM; DM DNA binding domain
    pfam08828
    Location:198 → 257
    DSX_dimer; Doublesex dimerization domain

  9. XM_062675971.1 → XP_062531955.1  doublesex isoform X3

  10. XM_062675974.1 → XP_062531958.1  doublesex isoform X8

  11. XM_062675973.1 → XP_062531957.1  doublesex isoform X8

Nucleotide Protein
Heading Accession and Version

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