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Trnt1 tRNA nucleotidyl transferase, CCA-adding, 1 [ Mus musculus (house mouse) ]

Gene ID: 70047, updated on 2-Nov-2024

Summary

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Official Symbol
Trnt1provided by MGI
Official Full Name
tRNA nucleotidyl transferase, CCA-adding, 1provided by MGI
Primary source
MGI:MGI:1917297
See related
Ensembl:ENSMUSG00000013736 AllianceGenome:MGI:1917297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-47; mt-Trat; 2410043H24Rik; 2610044E04Rik; 9830143O18Rik
Summary
Predicted to enable CCACCA tRNA nucleotidyltransferase activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in rescue of stalled ribosome and tRNA metabolic process. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.5), cerebellum adult (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trnt1 in Genome Data Viewer
Location:
6 E1; 6 49.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (106746099..106759435)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (106769138..106782474)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15631 Neighboring gene contactin 4 Neighboring gene STARR-seq mESC enhancer starr_16931 Neighboring gene STARR-seq mESC enhancer starr_16932 Neighboring gene STARR-seq mESC enhancer starr_16934 Neighboring gene STARR-seq mESC enhancer starr_16935 Neighboring gene STARR-seq mESC enhancer starr_16936 Neighboring gene STARR-positive B cell enhancer ABC_E6462 Neighboring gene STARR-positive B cell enhancer ABC_E4850 Neighboring gene STARR-positive B cell enhancer ABC_E9278 Neighboring gene STARR-seq mESC enhancer starr_16937 Neighboring gene STARR-positive B cell enhancer ABC_E3665 Neighboring gene interleukin 5 receptor, alpha Neighboring gene cereblon Neighboring gene predicted gene, 34873 Neighboring gene predicted gene, 22418

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. Nagaike T, et al. J Biol Chem, 2001 Oct 26. PMID 11504732
  2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CCA tRNA nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables CCA tRNA nucleotidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables CCACCA tRNA nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables CCACCA tRNA nucleotidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial tRNA 3'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rescue of stalled ribosome IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 3'-terminal CCA addition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 3'-terminal CCA addition ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 3'-terminal CCA addition ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within tRNA processing ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in tRNA surveillance IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA surveillance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISA
Inferred from Sequence Alignment
more info
 PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CCA tRNA nucleotidyltransferase 1, mitochondrial
Names
mitochondrial tRNA nucleotidyl transferase, CCA-adding
mt CCA-adding enzyme
mt tRNA CCA-diphosphorylase
mt tRNA CCA-pyrophosphorylase
mt tRNA adenylyltransferase
tRNA adenylyltransferase, mitochondrial
tRNA-nucleotidyltransferase 1, mitochondrial
NP_001229287.1
NP_001229289.1
NP_081572.1
XP_006506644.1
XP_036008188.1
XP_036008189.1
XP_036008190.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242358.1 → NP_001229287.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_001229287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK135791, AK139764, AK152739, BU755617
    Consensus CDS
    CCDS20397.1
    UniProtKB/Swiss-Prot
    Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0
    Related
    ENSMUSP00000060900.10, ENSMUST00000057578.16
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  2. NM_001242360.1 → NP_001229289.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001229289.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC153848, AK135791
    Consensus CDS
    CCDS57443.1
    UniProtKB/Swiss-Prot
    Q8K1J6
    Related
    ENSMUSP00000108873.2, ENSMUST00000113247.8
    Conserved Domains (1) summary
    COG0617
    Location:40 → 203
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  3. NM_027296.3 → NP_081572.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_081572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK135791, AK139764, BU755617
    Consensus CDS
    CCDS20397.1
    UniProtKB/Swiss-Prot
    Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0
    Related
    ENSMUSP00000108874.2, ENSMUST00000113248.4
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    106746099..106759435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152296.1 → XP_036008189.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl40750
    Location:17 → 329
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  2. XM_036152295.1 → XP_036008188.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  3. XM_006506581.5 → XP_006506644.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006506644.1

    UniProtKB/Swiss-Prot
    Q3TKW1, Q3UX99, Q8K1J6, Q920N6, Q9CSX0
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  4. XM_036152297.1 → XP_036008190.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl40750
    Location:17 → 329
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1J6.1 GenPept UniProtKB/Swiss-Prot:Q8K1J6

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