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IGF2 insulin like growth factor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 710802, updated on 17-Aug-2024

Summary

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Official Symbol
IGF2provided by VGNC
Official Full Name
insulin like growth factor 2provided by VGNC
Primary source
VGNC:VGNC:101281
See related
Ensembl:ENSMMUG00000047449
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See IGF2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
10
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (2192527..2219265, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (1954752..1981645, complement)

Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-675 Neighboring gene H19, imprinted maternally expressed transcript (non-protein coding) Neighboring gene uncharacterized LOC114672210 Neighboring gene insulin Neighboring gene tyrosine hydroxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells. Mitalipov S, et al. Stem Cells, 2007 Mar. PMID 17170068
  2. IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey. Ghosh D, et al. Reproduction, 2011 Apr. PMID 21292726
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. abnormal hypermethylation within the IGF2/H19 IC in all analyzed embryonic stem cell lines lines
    Title: Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells.
  2. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
    Title: IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor II

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041767.1 Reference Mmul_10 Primary Assembly

    Range
    2192527..2219265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015113346.2 → XP_014968832.2  insulin-like growth factor II isoform X2

    UniProtKB/TrEMBL
    A0A5F8AD35
    Related
    ENSMMUP00000075297.1, ENSMMUT00000106459.1
    Conserved Domains (2) summary
    cd04368
    Location:92 → 155
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:176 → 230
    IGF2_C; Insulin-like growth factor II E-peptide

  2. XM_028833047.1 → XP_028688880.1  insulin-like growth factor II isoform X1

    Conserved Domains (2) summary
    cd04368
    Location:92 → 158
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:179 → 233
    IGF2_C; Insulin-like growth factor II E-peptide

  3. XM_015113350.2 → XP_014968836.2  insulin-like growth factor II isoform X5

    UniProtKB/TrEMBL
    A0A1D5R7J7, G7NBL8
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  4. XM_015113347.2 → XP_014968833.2  insulin-like growth factor II isoform X3

    Conserved Domains (3) summary
    cd04368
    Location:84 → 150
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:171 → 225
    IGF2_C; Insulin-like growth factor II E-peptide
    cl00015
    Location:4 → 51
    nt_trans; nucleotidyl transferase superfamily

  5. XM_015113349.2 → XP_014968835.2  insulin-like growth factor II isoform X4

    UniProtKB/TrEMBL
    A0A5F7ZM98, G7NBL8
    Related
    ENSMMUP00000065740.1, ENSMMUT00000080772.1
    Conserved Domains (3) summary
    cd04368
    Location:84 → 147
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:168 → 222
    IGF2_C; Insulin-like growth factor II E-peptide
    cl00015
    Location:4 → 51
    nt_trans; nucleotidyl transferase superfamily

  6. XM_028833048.1 → XP_028688881.1  insulin-like growth factor II isoform X5

    UniProtKB/TrEMBL
    A0A1D5R7J7, G7NBL8
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  7. XM_015113351.2 → XP_014968837.2  insulin-like growth factor II isoform X5

    UniProtKB/TrEMBL
    A0A1D5R7J7, G7NBL8
    Related
    ENSMMUP00000056286.2, ENSMMUT00000075671.2
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  8. XM_015113352.2 → XP_014968838.2  insulin-like growth factor II isoform X5

    UniProtKB/TrEMBL
    A0A1D5R7J7, G7NBL8
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  9. XM_015113353.2 → XP_014968839.2  insulin-like growth factor II isoform X5

    UniProtKB/TrEMBL
    A0A1D5R7J7, G7NBL8
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide
Nucleotide Protein
Heading Accession and Version

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