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TNNT3 troponin T3, fast skeletal type [ Homo sapiens (human) ]

Gene ID: 7140, updated on 2-Nov-2024

Summary

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Official Symbol
TNNT3provided by HGNC
Official Full Name
troponin T3, fast skeletal typeprovided by HGNC
Primary source
HGNC:HGNC:11950
See related
Ensembl:ENSG00000130595 MIM:600692; AllianceGenome:HGNC:11950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNTF; DA2B2; beta-TnTF
Summary
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
Expression
Biased expression in esophagus (RPKM 25.1), prostate (RPKM 20.2) and 6 other tissues See more
Orthologs
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Genomic context

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See TNNT3 in Genome Data Viewer
Location:
11p15.5
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1919552..1938702)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1983592..2002746)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1940933..1959932)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lymphocyte specific protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4294 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1908437-1908603 Neighboring gene microRNA 7847 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:1918050-1919249 Neighboring gene proline rich 33 Neighboring gene long intergenic non-protein coding RNA 1150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1927717-1928218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1928219-1928718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4295 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1956346-1956534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1956988-1957585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1970491-1971228 Neighboring gene small nucleolar RNA, C/D box 131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1979269-1980047 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene VISTA enhancer hs1488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2003101-2003870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2004639-2005408 Neighboring gene H19/IGF2 enhancer region Neighboring gene MRPL23 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical analysis of a variant of Freeman-Sheldon syndrome (DA2B). Krakowiak PA, et al. Am J Med Genet, 1998 Feb 26. PMID 9508073
  2. A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus. Zhao N, et al. Eur J Med Genet, 2011 May-Jun. PMID 21402185
  3. The distal arthrogryposis-linked p.R63C variant promotes the stability and nuclear accumulation of TNNT3. Lu J, et al. J Clin Lab Anal, 2021 Dec. PMID 34766372, Free PMC Article
  4. Structure and sequence of the human fast skeletal troponin T (TNNT3) gene: insight into the evolution of the gene and the origin of the developmentally regulated isoforms. Stefancsik R, et al. Comp Funct Genomics, 2003. PMID 18629027, Free PMC Article
  5. Role of the fetal and alpha/beta exons in the function of fast skeletal troponin T isoforms: correlation with altered Ca2+ regulation associated with development. Chaudhuri T, et al. J Mol Biol, 2005 Sep 9. PMID 16081096

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The distal arthrogryposis-linked p.R63C variant promotes the stability and nuclear accumulation of TNNT3.
    Title: The distal arthrogryposis-linked p.R63C variant promotes the stability and nuclear accumulation of TNNT3.
  2. The TnT3 appears to contribute to age-related sarcopenia and possibly other age-related deficiencies such as muscle insulin resistance and beta cell dysfunction by interacting with TnT3-binding sequences in the promoter area of p53-related genes, among others, and consequently modulating the transcriptional regulation of these target genes.
    Title: Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs.
  3. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.
    Title: TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.
  4. The presence of the p.(Arg63His) missense mutation at position 63 of TNNT3 was confirmed through direct cycle sequencing of genomic DNA in six affected South African family members for whom DNA had been archived.
    Title: Digitotalar dysmorphism: Molecular elucidation.
  5. Data show that a missense mutation at nucleotide position 187 in exon 9 of the TNNT3 gene was identified in all affected individuals in the family.
    Title: A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus.
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  7. TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1.
    Title: Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2.
  8. Myotonic dystrophy type 2 muscles exhibited a higher degree of alternative splicing dysregulation for fast TnT transcripts when compared to myotonic dystrophy type 1 muscles.
    Title: Comparative transcriptional and biochemical studies in muscle of myotonic dystrophies (DM1 and DM2).
  9. Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot.
    Title: Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Arthrogryposis, distal, type 2B2
MedGen: C5193097 OMIM: 618435 GeneReviews: Not available
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EBI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
EBI GWAS Catalog
Genome-wide association study identifies five new breast cancer susceptibility loci.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp779M2348

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to tropomyosin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tropomyosin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables troponin C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables troponin C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables troponin I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables troponin I binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of calcium-dependent ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of striated muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
troponin T, fast skeletal muscle
Names
troponin T type 3 (skeletal, fast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013085.2 RefSeqGene

    Range
    5135..24134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_850

mRNA and Protein(s)

  1. NM_001042780.3 → NP_001036245.1  troponin T, fast skeletal muscle isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two internal coding exons and contains one different coding exon compared to transcript variant 1. However, it maintains the reading frame, and encodes a shorter isoform (3) with a different internal segment compared to isoform 1.
    Source sequence(s)
    BC050446, BC117327, BX640689, DA897990
    Consensus CDS
    CCDS41595.1
    UniProtKB/TrEMBL
    C9JZN9, F8WA37
    Related
    ENSP00000370991.3, ENST00000381579.7
    Conserved Domains (1) summary
    pfam00992
    Location:54 → 189
    Troponin; Troponin

  2. NM_001042781.3 → NP_001036246.1  troponin T, fast skeletal muscle isoform 2

    See identical proteins and their annotated locations for NP_001036246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two different internal coding exons and lacks another coding exon compared to transcript variant 1. However, it maintains the reading frame, and encodes a slightly shorter isoform (2) with a different internal segment compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
    Source sequence(s)
    BX640689, CR541927, DA897990
    Consensus CDS
    CCDS41594.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000371001.3, ENST00000381589.7
    Conserved Domains (1) summary
    pfam00992
    Location:60 → 195
    Troponin; Troponin

  3. NM_001042782.3 → NP_001036247.1  troponin T, fast skeletal muscle isoform 4

    See identical proteins and their annotated locations for NP_001036247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal coding exon compared to transcript variant 1, resulting in a shorter isoform (4) missing an 8 aa segment compared to isoform 1. Variants 4, 5, and 9 all encode the same isoform (4).
    Source sequence(s)
    BC117327, BX640689, DA897990
    Consensus CDS
    CCDS41596.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000370969.2, ENST00000381557.6
    Conserved Domains (1) summary
    pfam00992
    Location:54 → 189
    Troponin; Troponin

  4. NM_001297646.2 → NP_001284575.1  troponin T, fast skeletal muscle isoform 4

    See identical proteins and their annotated locations for NP_001284575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an internal coding exon compared to transcript variant 1, resulting in a shorter isoform (4) missing an 8 aa segment compared to isoform 1. Variants 4, 5, and 9 all encode the same isoform (4).
    Source sequence(s)
    AC051649, AK056968, DA897990, F26088
    Consensus CDS
    CCDS41596.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000370970.1, ENST00000381558.6
    Conserved Domains (1) summary
    pfam00992
    Location:54 → 189
    Troponin; Troponin

  5. NM_001363561.2 → NP_001350490.1  troponin T, fast skeletal muscle isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 12, encodes isoform 5.
    Source sequence(s)
    AC051649
    Consensus CDS
    CCDS86164.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000370975.4, ENST00000381563.8
    Conserved Domains (1) summary
    pfam00992
    Location:65 → 200
    Troponin; Troponin

  6. NM_001367842.1 → NP_001354771.1  troponin T, fast skeletal muscle isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC051649, BC171727
    Consensus CDS
    CCDS41594.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000492914.1, ENST00000641119.1

  7. NM_001367843.1 → NP_001354772.1  troponin T, fast skeletal muscle isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC051649
    UniProtKB/TrEMBL
    A0A9L9PY19, F8WA37
    Related
    ENSP00000516410.1, ENST00000706488.1

  8. NM_001367844.1 → NP_001354773.1  troponin T, fast skeletal muscle isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 4 and 5, encodes isoform 4.
    Source sequence(s)
    AC051649, BC117327
    Consensus CDS
    CCDS41596.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000493331.1, ENST00000641787.1

  9. NM_001367845.1 → NP_001354774.1  troponin T, fast skeletal muscle isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC051649
    UniProtKB/TrEMBL
    F8WA37

  10. NM_001367846.1 → NP_001354775.1  troponin T, fast skeletal muscle isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) encodes the longest isoform (8).
    Source sequence(s)
    AC051649
    Consensus CDS
    CCDS91403.1
    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
    UniProtKB/TrEMBL
    F8WA37

  11. NM_001367847.1 → NP_001354776.1  troponin T, fast skeletal muscle isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 6, encodes isoform 5.
    Source sequence(s)
    AC051649
    Consensus CDS
    CCDS86164.1
    UniProtKB/TrEMBL
    F8WA37

  12. NM_001367848.1 → NP_001354777.1  troponin T, fast skeletal muscle isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC051649
    UniProtKB/TrEMBL
    F8WA37

  13. NM_001367849.1 → NP_001354778.1  troponin T, fast skeletal muscle isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC051649
    UniProtKB/TrEMBL
    F8WA37

  14. NM_001367850.1 → NP_001354779.1  troponin T, fast skeletal muscle isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC051649
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000415614.1, ENST00000453458.5

  15. NM_001367851.1 → NP_001354780.1  troponin T, fast skeletal muscle isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 12.
    Source sequence(s)
    AC051649
    Consensus CDS
    CCDS91406.1
    UniProtKB/TrEMBL
    A0A286YFB1
    Conserved Domains (1) summary
    pfam00992
    Location:1 → 129
    Troponin

  16. NM_001367852.1 → NP_001354781.1  troponin T, fast skeletal muscle isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 12.
    Source sequence(s)
    AC051649, BC171728
    Consensus CDS
    CCDS91406.1
    UniProtKB/TrEMBL
    A0A286YFB1
    Related
    ENSP00000493372.1, ENST00000641225.1
    Conserved Domains (1) summary
    pfam00992
    Location:1 → 129
    Troponin

  17. NM_006757.4 → NP_006748.1  troponin T, fast skeletal muscle isoform 1

    See identical proteins and their annotated locations for NP_006748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC117327, BX640689, DA897990, M21984
    Consensus CDS
    CCDS7727.1
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000278317.6, ENST00000278317.11
    Conserved Domains (1) summary
    pfam00992
    Location:62 → 197
    Troponin; Troponin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1919552..1938702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018206.2 → XP_016873695.1  troponin T, fast skeletal muscle isoform X3

    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000380468.1, ENST00000397301.5
    Conserved Domains (1) summary
    pfam00992
    Location:73 → 208
    Troponin; Troponin

  2. XM_024448669.2 → XP_024304437.1  troponin T, fast skeletal muscle isoform X7

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:60 → 195
    Troponin; Troponin

  3. XM_017018207.2 → XP_016873696.1  troponin T, fast skeletal muscle isoform X4

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:69 → 204
    Troponin; Troponin

  4. XM_017018209.2 → XP_016873698.1  troponin T, fast skeletal muscle isoform X6

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:61 → 196
    Troponin; Troponin

  5. XM_017018211.2 → XP_016873700.1  troponin T, fast skeletal muscle isoform X9

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:56 → 191
    Troponin; Troponin

  6. XM_006718294.4 → XP_006718357.1  troponin T, fast skeletal muscle isoform X1

    UniProtKB/TrEMBL
    C9JZN9
    Conserved Domains (1) summary
    pfam00992
    Location:65 → 200
    Troponin; Troponin

  7. XM_017018205.2 → XP_016873694.1  troponin T, fast skeletal muscle isoform X2

    UniProtKB/TrEMBL
    A0A9L9PY19, F8WA37

  8. XM_006718299.3 → XP_006718362.1  troponin T, fast skeletal muscle isoform X20

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:53 → 189
    Troponin

  9. XM_006718300.4 → XP_006718363.1  troponin T, fast skeletal muscle isoform X21

    See identical proteins and their annotated locations for XP_006718363.1

    UniProtKB/TrEMBL
    F8WA37
    Related
    ENSP00000344870.4, ENST00000344578.8
    Conserved Domains (1) summary
    pfam00992
    Location:49 → 184
    Troponin; Troponin

  10. XM_017018216.2 → XP_016873705.1  troponin T, fast skeletal muscle isoform X17

    UniProtKB/TrEMBL
    F8WA37

  11. XM_017018217.2 → XP_016873706.1  troponin T, fast skeletal muscle isoform X18

    UniProtKB/TrEMBL
    F8WA37

  12. XM_017018218.2 → XP_016873707.1  troponin T, fast skeletal muscle isoform X19

    UniProtKB/TrEMBL
    F8WA37

  13. XM_017018219.2 → XP_016873708.1  troponin T, fast skeletal muscle isoform X22

    UniProtKB/TrEMBL
    C9JZN9, H9KVA2
    Related
    ENSP00000380471.2, ENST00000397304.6

  14. XM_011520343.3 → XP_011518645.1  troponin T, fast skeletal muscle isoform X3

    See identical proteins and their annotated locations for XP_011518645.1

    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:73 → 208
    Troponin; Troponin

  15. XM_017018208.2 → XP_016873697.1  troponin T, fast skeletal muscle isoform X5

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:66 → 201
    Troponin; Troponin

  16. XM_017018210.2 → XP_016873699.1  troponin T, fast skeletal muscle isoform X8

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:58 → 193
    Troponin; Troponin

  17. XM_024448671.2 → XP_024304439.1  troponin T, fast skeletal muscle isoform X12

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:53 → 189
    Troponin

  18. XM_017018214.2 → XP_016873703.1  troponin T, fast skeletal muscle isoform X14

    UniProtKB/TrEMBL
    C9JZN9, F8WA37
    Related
    ENSP00000413203.1, ENST00000446240.1
    Conserved Domains (1) summary
    pfam00992
    Location:49 → 184
    Troponin; Troponin

  19. XM_024448670.2 → XP_024304438.1  troponin T, fast skeletal muscle isoform X11

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:54 → 189
    Troponin

  20. XM_017018212.2 → XP_016873701.1  troponin T, fast skeletal muscle isoform X10

    UniProtKB/TrEMBL
    F8WA37

  21. XM_017018213.2 → XP_016873702.1  troponin T, fast skeletal muscle isoform X13

    UniProtKB/TrEMBL
    F8WA37

  22. XM_017018215.2 → XP_016873704.1  troponin T, fast skeletal muscle isoform X15

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:47 → 182
    Troponin; Troponin

  23. XM_024448672.2 → XP_024304440.1  troponin T, fast skeletal muscle isoform X16

    UniProtKB/TrEMBL
    F8WA37
    Conserved Domains (1) summary
    pfam00992
    Location:47 → 182
    Troponin; Troponin

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160004.1 Reference GRCh38.p14 PATCHES

    Range
    88376..107530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332449.1 → XP_054188424.1  troponin T, fast skeletal muscle isoform X3

    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

  2. XM_054332453.1 → XP_054188428.1  troponin T, fast skeletal muscle isoform X7

  3. XM_054332450.1 → XP_054188425.1  troponin T, fast skeletal muscle isoform X4

  4. XM_054332452.1 → XP_054188427.1  troponin T, fast skeletal muscle isoform X6

  5. XM_054332455.1 → XP_054188430.1  troponin T, fast skeletal muscle isoform X9

  6. XM_054332447.1 → XP_054188422.1  troponin T, fast skeletal muscle isoform X1

  7. XM_054332448.1 → XP_054188423.1  troponin T, fast skeletal muscle isoform X2

    UniProtKB/TrEMBL
    A0A9L9PY19

  8. XM_054332467.1 → XP_054188442.1  troponin T, fast skeletal muscle isoform X20

  9. XM_054332468.1 → XP_054188443.1  troponin T, fast skeletal muscle isoform X21

  10. XM_054332464.1 → XP_054188439.1  troponin T, fast skeletal muscle isoform X17

  11. XM_054332465.1 → XP_054188440.1  troponin T, fast skeletal muscle isoform X18

  12. XM_054332466.1 → XP_054188441.1  troponin T, fast skeletal muscle isoform X19

  13. XM_054332469.1 → XP_054188444.1  troponin T, fast skeletal muscle isoform X22

    UniProtKB/TrEMBL
    H9KVA2

  14. XM_054332463.1 → XP_054188438.1  troponin T, fast skeletal muscle isoform X3

    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

  15. XM_054332451.1 → XP_054188426.1  troponin T, fast skeletal muscle isoform X5

  16. XM_054332454.1 → XP_054188429.1  troponin T, fast skeletal muscle isoform X8

  17. XM_054332458.1 → XP_054188433.1  troponin T, fast skeletal muscle isoform X12

  18. XM_054332460.1 → XP_054188435.1  troponin T, fast skeletal muscle isoform X14

  19. XM_054332457.1 → XP_054188432.1  troponin T, fast skeletal muscle isoform X11

  20. XM_054332456.1 → XP_054188431.1  troponin T, fast skeletal muscle isoform X10

  21. XM_054332459.1 → XP_054188434.1  troponin T, fast skeletal muscle isoform X13

  22. XM_054332461.1 → XP_054188436.1  troponin T, fast skeletal muscle isoform X15

  23. XM_054332462.1 → XP_054188437.1  troponin T, fast skeletal muscle isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1983592..2002746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369780.1 → XP_054225755.1  troponin T, fast skeletal muscle isoform X3

    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

  2. XM_054369784.1 → XP_054225759.1  troponin T, fast skeletal muscle isoform X7

  3. XM_054369781.1 → XP_054225756.1  troponin T, fast skeletal muscle isoform X4

  4. XM_054369783.1 → XP_054225758.1  troponin T, fast skeletal muscle isoform X6

  5. XM_054369786.1 → XP_054225761.1  troponin T, fast skeletal muscle isoform X9

  6. XM_054369778.1 → XP_054225753.1  troponin T, fast skeletal muscle isoform X1

  7. XM_054369779.1 → XP_054225754.1  troponin T, fast skeletal muscle isoform X2

    UniProtKB/TrEMBL
    A0A9L9PY19

  8. XM_054369798.1 → XP_054225773.1  troponin T, fast skeletal muscle isoform X20

  9. XM_054369799.1 → XP_054225774.1  troponin T, fast skeletal muscle isoform X21

  10. XM_054369795.1 → XP_054225770.1  troponin T, fast skeletal muscle isoform X17

  11. XM_054369796.1 → XP_054225771.1  troponin T, fast skeletal muscle isoform X18

  12. XM_054369797.1 → XP_054225772.1  troponin T, fast skeletal muscle isoform X19

  13. XM_054369800.1 → XP_054225775.1  troponin T, fast skeletal muscle isoform X22

    UniProtKB/TrEMBL
    H9KVA2

  14. XM_054369794.1 → XP_054225769.1  troponin T, fast skeletal muscle isoform X3

    UniProtKB/Swiss-Prot
    A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

  15. XM_054369782.1 → XP_054225757.1  troponin T, fast skeletal muscle isoform X5

  16. XM_054369785.1 → XP_054225760.1  troponin T, fast skeletal muscle isoform X8

  17. XM_054369789.1 → XP_054225764.1  troponin T, fast skeletal muscle isoform X12

  18. XM_054369791.1 → XP_054225766.1  troponin T, fast skeletal muscle isoform X14

  19. XM_054369788.1 → XP_054225763.1  troponin T, fast skeletal muscle isoform X11

  20. XM_054369787.1 → XP_054225762.1  troponin T, fast skeletal muscle isoform X10

  21. XM_054369790.1 → XP_054225765.1  troponin T, fast skeletal muscle isoform X13

  22. XM_054369792.1 → XP_054225767.1  troponin T, fast skeletal muscle isoform X15

  23. XM_054369793.1 → XP_054225768.1  troponin T, fast skeletal muscle isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45378.3 GenPept UniProtKB/Swiss-Prot:P45378

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