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VEGFB vascular endothelial growth factor B [ Homo sapiens (human) ]

Gene ID: 7423, updated on 4-Jan-2025

Summary

Official Symbol
VEGFBprovided by HGNC
Official Full Name
vascular endothelial growth factor Bprovided by HGNC
Primary source
HGNC:HGNC:12681
See related
Ensembl:ENSG00000173511 MIM:601398; AllianceGenome:HGNC:12681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VRF; VEGFL
Summary
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Expression
Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues See more
Orthologs
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Genomic context

See VEGFB in Genome Data Viewer
Location:
11q13.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64234584..64239264)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64224529..64229291)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64002056..64006736)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene nudix hydrolase 22 Neighboring gene uncharacterized LOC124902687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3467 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64007574-64008476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64008477-64009377 Neighboring gene uncharacterized LOC114841035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64010280-64011180 Neighboring gene FKBP prolyl isomerase 2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene PPP1R14B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3470

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed
tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
tat HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus vIL-6-induced cell proliferation, cellular transformation, vascular tube formation, and VEGF production in tumor cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity  
enables chemoattractant activity PubMed 
enables growth factor activity  
enables heparin binding  
enables identical protein binding  
enables protein binding PubMed 
enables vascular endothelial growth factor receptor 1 binding PubMed 
enables vascular endothelial growth factor receptor binding  
Process Evidence Code Pubs
involved_in cardiac muscle contraction  
involved_in coronary vasculature development  
involved_in induction of positive chemotaxis  
involved_in induction of positive chemotaxis PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of neuron apoptotic process PubMed 
involved_in positive chemotaxis  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of cell division  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of endothelial cell proliferation PubMed 
involved_in positive regulation of mast cell chemotaxis  
involved_in positive regulation of mast cell chemotaxis PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway PubMed 
NOT involved_in positive regulation of vascular permeability PubMed 
involved_in positive regulation of vascular wound healing PubMed 
involved_in protein O-linked glycosylation  
involved_in response to hypoxia  
involved_in sprouting angiogenesis  
involved_in vascular endothelial growth factor receptor signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in membrane  
located_in platelet alpha granule lumen  

General protein information

Preferred Names
vascular endothelial growth factor B
Names
VEGF-related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029823.1 RefSeqGene

    Range
    5001..9681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243733.2NP_001230662.1  vascular endothelial growth factor B isoform VEGFB-167 precursor

    See identical proteins and their annotated locations for NP_001230662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (VEGFB-167) lacks a segment in the 3' coding region, resulting in a downstream stop codon, compared to variant VEGFB-186. The resulting isoform (VEGFB-167, also known as VRF167) has a shorter and distinct C-terminus, compared to isoform VEGFB-186. This isoform contains the heparin binding domain and is mostly sequestered in the extracellular matrix.
    Source sequence(s)
    AP001453, BG031449, BM694361, BU730521, U48801
    Consensus CDS
    CCDS58144.1
    UniProtKB/TrEMBL
    Q8TEV2
    Related
    ENSP00000401550.2, ENST00000426086.3
    Conserved Domains (1) summary
    smart00141
    Location:45126
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  2. NM_003377.5NP_003368.1  vascular endothelial growth factor B isoform VEGFB-186 precursor

    See identical proteins and their annotated locations for NP_003368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (VEGFB-186) encodes the longer isoform (VEGFB-186, also known as VRF186). This isoform lacks the heparin binding domain and is secreted freely from cells.
    Source sequence(s)
    AP001453, BC008818, BM694361, BU730521
    Consensus CDS
    CCDS8062.1
    UniProtKB/Swiss-Prot
    P49765, Q16528
    UniProtKB/TrEMBL
    Q7LAP4
    Related
    ENSP00000311127.2, ENST00000309422.7
    Conserved Domains (2) summary
    PHA03269
    Location:108188
    PHA03269; envelope glycoprotein C; Provisional
    smart00141
    Location:45126
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64234584..64239264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64224529..64229291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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