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Spdye4a speedy/RINGO cell cycle regulator family, member E4A [ Mus musculus (house mouse) ]

Gene ID: 74673, updated on 2-Nov-2024

Summary

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Official Symbol
Spdye4aprovided by MGI
Official Full Name
speedy/RINGO cell cycle regulator family, member E4Aprovided by MGI
Primary source
MGI:MGI:1921923
See related
Ensembl:ENSMUSG00000039296 AllianceGenome:MGI:1921923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spdy2; Spdyb; Spdye4; RINGO E4A; Spy/Ringo B; 4930445A17Rik; 4930451F05Rik
Summary
Enables protein kinase binding activity. Involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in nucleus. Is expressed in testis. Orthologous to several human genes including SPDYE4 (speedy/RINGO cell cycle regulator family member E4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 5.6) See more
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Genomic context

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See Spdye4a in Genome Data Viewer
Location:
5 G2; 5 82.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143202070..143212657, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143216315..143226902, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RB-associated KRAB zinc finger Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143942516-143942699 Neighboring gene speedy/RINGO cell cycle regulator family, member E4B Neighboring gene RIKEN cDNA 4930448H16 gene Neighboring gene predicted gene, 38735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143996641-143996853 Neighboring gene zinc finger protein 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene. Xu H, et al. Gen Comp Endocrinol, 2023 Jan 1. PMID 36272447
  2. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng A, et al. Cell Cycle, 2005 Jan. PMID 15611625
  3. Characterization of a new family of cyclin-dependent kinase activators. Dinarina A, et al. Biochem J, 2005 Mar 1. PMID 15574121, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.
    Title: Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
speedy protein E4A
Names
mSpy/Ringo B
mSpy/Ringo E4A
rapid inducer of G2/M progression in oocytes B
rapid inducer of G2/M progression in oocytes E4A
speedy homolog 2
speedy homolog E4
speedy protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310757.1 → NP_001297686.1  speedy protein E4A isoform 2

    See identical proteins and their annotated locations for NP_001297686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AC123686, AK015385, AK015441
    Consensus CDS
    CCDS80456.1
    UniProtKB/TrEMBL
    B9EIX3
    Related
    ENSMUSP00000123959.2, ENSMUST00000160502.2
    Conserved Domains (1) summary
    pfam11357
    Location:98 → 156
    Spy1; Cell cycle regulatory protein

  2. NM_029048.3 → NP_083324.3  speedy protein E4A isoform 1

    See identical proteins and their annotated locations for NP_083324.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123686, AK015441
    Consensus CDS
    CCDS39368.1
    UniProtKB/Swiss-Prot
    Q5IBH6
    Related
    ENSMUSP00000082882.3, ENSMUST00000085733.9
    Conserved Domains (1) summary
    pfam11357
    Location:135 → 264
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143202070..143212657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504749.3 → XP_006504812.1  speedy protein E4A isoform X1

    UniProtKB/TrEMBL
    A0A0G2JEI8
    Related
    ENSMUSP00000142788.2, ENSMUST00000195900.5
    Conserved Domains (1) summary
    pfam11357
    Location:101 → 227
    Spy1; Cell cycle regulatory protein

  2. XM_011240987.4 → XP_011239289.1  speedy protein E4A isoform X2

    Conserved Domains (1) summary
    pfam11357
    Location:138 → 193
    Spy1; Cell cycle regulatory protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IBH6.1 GenPept UniProtKB/Swiss-Prot:Q5IBH6

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