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tmem14ca transmembrane protein 14Ca [ Danio rerio (zebrafish) ]

Gene ID: 751728, updated on 2-Nov-2024

Summary

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Official Symbol
tmem14caprovided by ZNC
Official Full Name
transmembrane protein 14Caprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-156
See related
Ensembl:ENSDARG00000110836 AllianceGenome:ZFIN:ZDB-GENE-060825-156
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tmem14c; zgc:153439
Summary
Acts upstream of or within heme biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. Is expressed in intermediate cell mass of mesoderm and ventral wall of dorsal aorta. Orthologous to several human genes including TMEM14C (transmembrane protein 14C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tmem14ca in Genome Data Viewer
Location:
chromosome: 24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (8736493..8741837)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (8596089..8601452)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B3 Neighboring gene transcription factor AP-2 alpha Neighboring gene male germ cell-associated kinase Neighboring gene uncharacterized LOC110438349 Neighboring gene glial cells missing transcription factor 2 Neighboring gene synaptonemal complex protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Nilsson R, et al. Cell Metab, 2009 Aug. PMID 19656490, Free PMC Article
  2. Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish. Covassin L, et al. Dev Biol, 2006 Nov 15. PMID 16999953, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Required for functional heme biosynthesis in erythroid cells.
    Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC153439

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 14C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045438.1 → NP_001038903.1  transmembrane protein 14C

    See identical proteins and their annotated locations for NP_001038903.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122294
    UniProtKB/Swiss-Prot
    Q0P436
    Related
    ENSDARP00000152761.1, ENSDART00000181904.1
    Conserved Domains (1) summary
    pfam03647
    Location:5 → 94
    Tmemb_14; Transmembrane proteins 14C

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    8736493..8741837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162574.5 → XP_005162631.3  transmembrane protein 14C isoform X1

  2. XM_005162575.5 → XP_005162632.1  transmembrane protein 14C isoform X2

    UniProtKB/TrEMBL
    A0A2R8QK55, A0A8M2B9G8
    Conserved Domains (1) summary
    pfam03647
    Location:5 → 94
    Tmemb_14; Transmembrane proteins 14C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P436.1 GenPept UniProtKB/Swiss-Prot:Q0P436

Gene LinkOut

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