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Rbm12 RNA binding motif protein 12 [ Mus musculus (house mouse) ]

Gene ID: 75710, updated on 2-Nov-2024

Summary

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Official Symbol
Rbm12provided by MGI
Official Full Name
RNA binding motif protein 12provided by MGI
Primary source
MGI:MGI:1922960
See related
Ensembl:ENSMUSG00000089824 AllianceGenome:MGI:1922960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SWAN; mKIAA0765; 5730420G12Rik; 9430070C08Rik
Summary
This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thymus adult (RPKM 9.7), CNS E11.5 (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rbm12 in Genome Data Viewer
Location:
2 H1; 2 77.35 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155933876..155953847, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156094882..156111965, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39970 Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene STARR-seq mESC enhancer starr_06153 Neighboring gene STARR-positive B cell enhancer ABC_E3414 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. Sun M, et al. G3 (Bethesda), 2012 Jan. PMID 22384391, Free PMC Article
  2. Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2. Jerez-Timaure NC, et al. Physiol Genomics, 2005 May 11. PMID 15769905
  3. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30712, MGC38279

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 12
Names
SH3/WW domain anchor protein in the nucleus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029397.4 → NP_083673.3  RNA-binding protein 12

    See identical proteins and their annotated locations for NP_083673.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AL833786
    Consensus CDS
    CCDS16961.1
    UniProtKB/Swiss-Prot
    B6ICZ5, Q3TKT7, Q7TT14, Q8K373, Q8R302, Q8R4X3, Q9CS80
    Related
    ENSMUSP00000050461.6, ENSMUST00000059647.12
    Conserved Domains (6) summary
    COG0724
    Location:401 → 610
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12512
    Location:421 → 521
    RRM3_RBM12; RNA recognition motif 3 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12745
    Location:1 → 92
    RRM1_RBM12; RNA recognition motif 1 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12747
    Location:303 → 377
    RRM2_RBM12; RNA recognition motif 2 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12749
    Location:545 → 632
    RRM4_RBM12; RNA recognition motif 4 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12751
    Location:915 → 989
    RRM5_RBM12; RNA recognition motif 5 in RNA-binding protein 12 (RBM12) and similar proteins

  2. NM_170598.3 → NP_733486.2  RNA-binding protein 12

    See identical proteins and their annotated locations for NP_733486.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site which creates a shorter 5' UTR when compared to variant 1.
    Source sequence(s)
    AL833786
    Consensus CDS
    CCDS16961.1
    UniProtKB/Swiss-Prot
    B6ICZ5, Q3TKT7, Q7TT14, Q8K373, Q8R302, Q8R4X3, Q9CS80
    Related
    ENSMUSP00000105233.2, ENSMUST00000109604.9
    Conserved Domains (6) summary
    COG0724
    Location:401 → 610
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12512
    Location:421 → 521
    RRM3_RBM12; RNA recognition motif 3 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12745
    Location:1 → 92
    RRM1_RBM12; RNA recognition motif 1 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12747
    Location:303 → 377
    RRM2_RBM12; RNA recognition motif 2 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12749
    Location:545 → 632
    RRM4_RBM12; RNA recognition motif 4 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12751
    Location:915 → 989
    RRM5_RBM12; RNA recognition motif 5 in RNA-binding protein 12 (RBM12) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155933876..155953847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4X3.3 GenPept UniProtKB/Swiss-Prot:Q8R4X3

Gene LinkOut

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