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ZNF33B zinc finger protein 33B [ Homo sapiens (human) ]

Gene ID: 7582, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF33Bprovided by HGNC
Official Full Name
zinc finger protein 33Bprovided by HGNC
Primary source
HGNC:HGNC:13097
See related
Ensembl:ENSG00000196693 MIM:194522; AllianceGenome:HGNC:13097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX2; KOX31; ZNF11B
Summary
This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in thyroid (RPKM 8.1), kidney (RPKM 6.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
10q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (42574169..42638570, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (43451702..43516055, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (43069617..43134018, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 1 Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 2 Neighboring gene RNA, U6 small nuclear 1170, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:43132780-43133648 Neighboring gene uncharacterized LOC105378268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2311 Neighboring gene Sharpr-MPRA regulatory region 10386 Neighboring gene vomeronasal 1 receptor 54 pseudogene Neighboring gene long intergenic non-protein coding RNA 1518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma. Lee S, et al. Eur Respir J, 2023 Jan. PMID 35953101, Free PMC Article
  2. Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. de los Santos MJ, et al. Hum Reprod, 2012 Jun. PMID 22451503
  3. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Rousseau-Merck MF, et al. Genomics, 1992 Jul. PMID 1639412
  4. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy J, et al. Genome Res, 2003 Feb. PMID 12566394, Free PMC Article
  5. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.
    Title: Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23327, MGC129696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 33B
Names
zinc finger protein 11b (KOX 2)
zinc finger protein 33b (KOX 31)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305033.2 → NP_001291962.1  zinc finger protein 33B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AJ491697, AK310073, BG536481
    UniProtKB/Swiss-Prot
    Q06732
    Related
    ENSP00000481265.1, ENST00000613419.4
    Conserved Domains (6) summary
    smart00349
    Location:19 → 78
    KRAB; krueppel associated box
    COG5048
    Location:336 → 681
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476 → 498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:19 → 58
    KRAB; KRAB box
    pfam13465
    Location:378 → 403
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001305035.2 → NP_001291964.1  zinc finger protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001291964.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
    Source sequence(s)
    AJ491697, AK310073
    UniProtKB/Swiss-Prot
    Q06732
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001305036.2 → NP_001291965.1  zinc finger protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001291965.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
    Source sequence(s)
    AJ491697, AK310073, DA230792
    UniProtKB/Swiss-Prot
    Q06732
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001305037.2 → NP_001291966.1  zinc finger protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001291966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
    Source sequence(s)
    AJ491697, AK310073, DB156590
    UniProtKB/Swiss-Prot
    Q06732
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001305038.2 → NP_001291967.1  zinc finger protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001291967.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
    Source sequence(s)
    AJ491697, AK310073, CD652356
    UniProtKB/Swiss-Prot
    Q06732
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001305039.2 → NP_001291968.1  zinc finger protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001291968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
    Source sequence(s)
    AJ491697, AK310073, DA493121
    UniProtKB/Swiss-Prot
    Q06732
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001305040.2 → NP_001291969.1  zinc finger protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001291969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
    Source sequence(s)
    AJ491697, AK310073, DR000119
    UniProtKB/Swiss-Prot
    Q06732
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  8. NM_006955.3 → NP_008886.1  zinc finger protein 33B isoform 2

    See identical proteins and their annotated locations for NP_008886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, contains an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AJ491697, AK310073
    Consensus CDS
    CCDS7198.1
    UniProtKB/Swiss-Prot
    Q06731, Q06732, Q32MA2, Q86XY8, Q8NDW3
    Related
    ENSP00000352444.2, ENST00000359467.8
    Conserved Domains (5) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:329 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:371 → 396
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_130948.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK096683, AK309564, AK310073, AL022345, BI258188

  2. NR_130949.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK096683, AK310073, AL022345, BI258188
    Related
    ENST00000486187.5

  3. NR_130950.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK096683, AK310073, AL022345, BI258188, DA959465

  4. NR_130951.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK310073, BC042873, DA826003

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    42574169..42638570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425718.1 → XP_047281674.1  zinc finger protein 33B isoform X1

  2. XM_047425719.1 → XP_047281675.1  zinc finger protein 33B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    43451702..43516055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366693.1 → XP_054222668.1  zinc finger protein 33B isoform X1

  2. XM_054366694.1 → XP_054222669.1  zinc finger protein 33B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06732.2 GenPept UniProtKB/Swiss-Prot:Q06732

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