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rgs9a regulator of G protein signaling 9a [ Danio rerio (zebrafish) ]

Gene ID: 767636, updated on 18-Sep-2024

Summary

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Official Symbol
rgs9aprovided by ZNC
Official Full Name
regulator of G protein signaling 9aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-92
See related
Ensembl:ENSDARG00000037925 AllianceGenome:ZFIN:ZDB-GENE-060929-92
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rgs9; wipi1; zgc:152760
Summary
Predicted to act upstream of or within G protein-coupled receptor signaling pathway; intracellular signal transduction; and negative regulation of signal transduction. Human ortholog(s) of this gene implicated in bradyopsia. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See rgs9a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36366546..36401994)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36236948..36259806)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 6b Neighboring gene guanine nucleotide binding protein (G protein), alpha 13b Neighboring gene si:ch1073-443f11.2 Neighboring gene component of oligomeric golgi complex 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Dong XR, et al. Front Cell Dev Biol, 2022. PMID 35372349, Free PMC Article
  2. Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Pinto CL, et al. Mol Cell Endocrinol, 2016 Jan 5. PMID 26427652, Free PMC Article
  3. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Zhang P, et al. Cell Rep, 2014 Mar 27. PMID 24613356
  4. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. Saddala MS, et al. BMC Genomics, 2020 Feb 7. PMID 32033529, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC152760

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 9a
Names
WD repeat domain, phosphoinositide interacting 1
regulator of G-protein signaling 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327800.1 → NP_001314729.1  regulator of G-protein signaling 9a

    Status: VALIDATED

    Source sequence(s)
    CABZ01019467, CU855789, LO018534
    UniProtKB/TrEMBL
    A0A2R8QUQ1, A0A8M1P8B2
    Related
    ENSDARP00000157261.1, ENSDART00000181140.1
    Conserved Domains (3) summary
    smart00224
    Location:223 → 283
    GGL; G protein gamma subunit-like motifs
    cd04450
    Location:25 → 112
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl02565
    Location:295 → 415
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    36366546..36401994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217649.1 → XP_068073750.1  regulator of G-protein signaling 9a isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001076577.2: Suppressed sequence

    Description
    NM_001076577.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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