grin1a glutamate receptor, ionotropic, N-methyl D-aspartate 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grin1aprovided by ZNC
Official Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051202-1
See related: Ensembl:ENSDARG00000027828 AllianceGenome:ZFIN:ZDB-GENE-051202-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NMDAR1.1; zgc:152678
Summary: Enables ligand-gated ion channel activity. Involved in calcium ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (11468587..11502971)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (11375917..11410343)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	IPI Inferred from Physical Interaction more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in ionotropic glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 1a; glutamate receptor, ionotropic, N-methyl D-aspartate 1a

Names: NMDA receptor glycine-binding subunit NR1.1; round spermatid basic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076714.2 → NP_001070182.2 glutamate receptor ionotropic, NMDA 1a precursor

Status: VALIDATED

Source sequence(s)

BX005379

UniProtKB/TrEMBL

A0A8M1NB21, F1R366

Related

ENSDARP00000093144.4, ENSDART00000102368.5

Conserved Domains (5) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 815

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:577 → 840

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 372

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:851 → 879

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

11468587..11502971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161061.4 → XP_005161118.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X1

UniProtKB/TrEMBL

A0A8M2B7Z4

Conserved Domains (5) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 819

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:581 → 844

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 372

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:855 → 883

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_021468911.1 → XP_021324586.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X3

UniProtKB/TrEMBL

A0A8M9PQL9

Conserved Domains (3) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 819

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:855 → 883

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_009295217.3 → XP_009293492.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X4

UniProtKB/TrEMBL

A0A8M3ALB6

Conserved Domains (5) summary

cd06379
Location:5 → 380

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:392 → 798

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:560 → 823

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 351

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:834 → 862

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_005161068.4 → XP_005161125.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X6

UniProtKB/TrEMBL

A0A8M2B802

Conserved Domains (5) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 819

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:581 → 844

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 372

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:855 → 883

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_009295219.3 → XP_009293494.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X5

UniProtKB/TrEMBL

A0A8M3B4K1

Conserved Domains (5) summary

cd06379
Location:5 → 380

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:392 → 794

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:556 → 819

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 351

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:830 → 858

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_005161069.4 → XP_005161126.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X7

UniProtKB/TrEMBL

A0A8M2B7Z7

Conserved Domains (5) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 819

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:581 → 844

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 372

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:855 → 883

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_021468914.1 → XP_021324589.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X9

UniProtKB/TrEMBL

A0A8M9PIG4

Conserved Domains (3) summary

cd06379
Location:5 → 380

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:392 → 794

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:830 → 858

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_005161070.4 → XP_005161127.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X10

UniProtKB/TrEMBL

A0A8M2B7Z5

Conserved Domains (5) summary

cd06379
Location:5 → 380

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:392 → 794

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:556 → 819

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 351

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:830 → 858

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_021468913.1 → XP_021324588.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X8

UniProtKB/TrEMBL

A0A8M9PCT9

Conserved Domains (3) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 815

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:851 → 879

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_009295216.3 → XP_009293491.1 glutamate receptor, ionotropic, N-methyl D-aspartate 1a isoform X2

UniProtKB/TrEMBL

A0A8M3ATQ3

Conserved Domains (5) summary

cd06379
Location:5 → 401

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:413 → 815

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:577 → 840

Lig_chan; Ligand-gated ion channel

pfam01094
Location:54 → 372

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:851 → 879

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit