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ZNF146 zinc finger protein 146 [ Homo sapiens (human) ]

Gene ID: 7705, updated on 17-Jun-2024

Summary

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Official Symbol
ZNF146provided by HGNC
Official Full Name
zinc finger protein 146provided by HGNC
Primary source
HGNC:HGNC:12931
See related
Ensembl:ENSG00000167635 MIM:601505; AllianceGenome:HGNC:12931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OZF
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 20.8), endometrium (RPKM 19.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF146 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36214723..36238768)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38763116..38787183)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36706008..36729670)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14519 Neighboring gene calpain small subunit 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36646245-36646976 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678024-36678563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678564-36679102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36683570-36684070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36684071-36684571 Neighboring gene zinc finger protein 565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14521 Neighboring gene uncharacterized LOC107985304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724474-36724976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724977-36725478 Neighboring gene MPRA-validated peak3458 silencer Neighboring gene MPRA-validated peak3459 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36735657-36736645 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36736677-36736900 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:36737634-36738622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36748697-36749315 Neighboring gene uncharacterized LOC124904707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36759575-36760152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36762631-36763222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36770206-36770810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36775291-36775913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36786728-36787343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36787344-36787958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36790483-36791084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36791085-36791685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36793635-36794244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36796811-36797424 Neighboring gene uncharacterized LOC100134317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains. Pibouin L, et al. Cytogenet Cell Genet, 2001. PMID 11306801
  2. Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas. Ferbus D, et al. Int J Cancer, 1999 Jan 29. PMID 9935176
  3. Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs. Ferbus D, et al. Eur J Biochem, 1996 Mar 15. PMID 8665923
  4. The OZF gene encodes a protein consisting essentially of zinc finger motifs. Le Chalony C, et al. J Mol Biol, 1994 Feb 18. PMID 8107129
  5. ZNF146/OZF and ZNF507 target LINE-1 sequences. Creamer KM, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100360, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells.
    Title: ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells.
  2. Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.
    Title: Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.
  3. ZNF146/OZF and ZNF507 target LINE-1 sequences.
    Title: ZNF146/OZF and ZNF507 target LINE-1 sequences.
  4. LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146.
    Title: LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146.
  5. OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress.
    Title: OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress.
  6. OZF overexpression in tumours may alter the balance between hRap1 and other telomeric proteins; therefore OZF function may be linked to telomere regulation
    Title: Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.
  7. OZF interacts with UBC9, the E2 enzyme involved in the covalent conjugation of the small ubiquitin-like modifier 1 (SUMO-1).
    Title: A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125660, MGC125661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein OZF
Names
only zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099638.2 → NP_001093108.1  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_001093108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI039686, BC065568, DA645504, DA806687, DR155969
    Consensus CDS
    CCDS12492.1
    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Related
    ENSP00000400391.1, ENST00000456324.5
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:74 → 94
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001099639.2 → NP_001093109.1  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_001093109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI039686, BC065568, CN409203, DA645504, DB068031, DR155969
    Consensus CDS
    CCDS12492.1
    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:74 → 94
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  3. NM_007145.3 → NP_009076.2  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_009076.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI039686, BC065568, DA395000, DA645504, DR155969
    Consensus CDS
    CCDS12492.1
    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Related
    ENSP00000392095.1, ENST00000443387.3
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:74 → 94
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36214723..36238768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439366.1 → XP_047295322.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  2. XM_017027247.3 → XP_016882736.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:74 → 94
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047439367.1 → XP_047295323.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  4. XM_047439365.1 → XP_047295321.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  5. XM_017027246.3 → XP_016882735.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:74 → 94
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  6. XM_047439368.1 → XP_047295324.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  7. XM_005259214.4 → XP_005259271.1  zinc finger protein OZF isoform X1

    See identical proteins and their annotated locations for XP_005259271.1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:74 → 94
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38763116..38787183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322012.1 → XP_054177987.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  2. XM_054322015.1 → XP_054177990.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  3. XM_054322016.1 → XP_054177991.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  4. XM_054322013.1 → XP_054177988.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  5. XM_054322014.1 → XP_054177989.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  6. XM_054322010.1 → XP_054177985.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94

  7. XM_054322011.1 → XP_054177986.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    Q15072, Q2TB94
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15072.2 GenPept UniProtKB/Swiss-Prot:Q15072

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