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Axdnd1 axonemal dynein light chain domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 77352, updated on 2-Nov-2024

Summary

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Official Symbol
Axdnd1provided by MGI
Official Full Name
axonemal dynein light chain domain containing 1provided by MGI
Primary source
MGI:MGI:1924602
See related
Ensembl:ENSMUSG00000026601 AllianceGenome:MGI:1924602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm979; 9430070O13Rik
Summary
Involved in manchette assembly. Located in cytoplasm. Orthologous to human AXDND1 (axonemal dynein light chain domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 15.3) See more
Orthologs
human all
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Genomic context

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See Axdnd1 in Genome Data Viewer
Location:
1 G3; 1 67.71 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156157985..156248743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156330415..156421176, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158194711-158194894 Neighboring gene STARR-seq mESC enhancer starr_02735 Neighboring gene tudor domain containing 5 Neighboring gene nephrosis 2, podocin Neighboring gene ribosomal protein L35, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_02736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158338195-158338508 Neighboring gene STARR-positive B cell enhancer ABC_E3317 Neighboring gene STARR-positive B cell enhancer ABC_E9485 Neighboring gene sterol O-acyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2571 Neighboring gene STARR-positive B cell enhancer mm9_chr1:158404407-158404707 Neighboring gene predicted gene, 39682

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice. Hiradate Y, et al. Reprod Med Biol, 2022 Jan-Dec. PMID 35386379, Free PMC Article
  2. AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans. Houston BJ, et al. Cell Death Dis, 2024 Jul 12. PMID 38997255, Free PMC Article
  3. AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility. Ma Q, et al. Cell Death Discov, 2021 Nov 11. PMID 34759295, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.
    Title: AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in manchette assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
axonemal dynein light chain domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346967.1 → NP_001333896.1  axonemal dynein light chain domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC161221, AC161414
    Consensus CDS
    CCDS83611.1
    UniProtKB/Swiss-Prot
    A0A1D5RLL5, Q3UZ57
    UniProtKB/TrEMBL
    J3QPL7
    Related
    ENSMUSP00000148420.2, ENSMUST00000213088.3
    Conserved Domains (1) summary
    pfam10211
    Location:209 → 364
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    156157985..156248743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243577.2 → XP_030099437.1  axonemal dynein light chain domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A0A1D5RLL5, Q3UZ57
    UniProtKB/TrEMBL
    J3QPL7
    Related
    ENSMUSP00000137354.2, ENSMUST00000178036.8
    Conserved Domains (1) summary
    pfam10211
    Location:209 → 364
    Ax_dynein_light; Axonemal dynein light chain

  2. XM_030243584.2 → XP_030099444.1  axonemal dynein light chain domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    J3QPL7
    Related
    ENSMUSP00000135900.2, ENSMUST00000177824.8
    Conserved Domains (1) summary
    pfam10211
    Location:168 → 323
    Ax_dynein_light; Axonemal dynein light chain

  3. XM_036154380.1 → XP_036010273.1  axonemal dynein light chain domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    J3KMJ8
    Conserved Domains (1) summary
    pfam10211
    Location:101 → 207
    Ax_dynein_light; Axonemal dynein light chain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033180.2: Suppressed sequence

    Description
    NM_001033180.2: This RefSeq was temporarily suppressed because the CDS was partial.

  2. NM_001198597.1: Suppressed sequence

    Description
    NM_001198597.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UZ57.2 GenPept UniProtKB/Swiss-Prot:Q3UZ57

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials