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ZNF227 zinc finger protein 227 [ Homo sapiens (human) ]

Gene ID: 7770, updated on 17-Jun-2024

Summary

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Official Symbol
ZNF227provided by HGNC
Official Full Name
zinc finger protein 227provided by HGNC
Primary source
HGNC:HGNC:13020
See related
Ensembl:ENSG00000131115 AllianceGenome:HGNC:13020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 4.1), testis (RPKM 3.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF227 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44207547..44237268)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47030346..47060129)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44716685..44741421)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene zinc finger protein 234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene uncharacterized LOC124904726 Neighboring gene zinc finger protein 233 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene zinc finger protein 235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  3. Identification of novel ARF binding proteins by two-hybrid screening. Tompkins V, et al. Cell Cycle, 2006 Mar. PMID 16582619
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  5. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 227

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289166.2 → NP_001276095.1  zinc finger protein 227 isoform a

    See identical proteins and their annotated locations for NP_001276095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK092253, AL833012
    Consensus CDS
    CCDS12636.1
    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6
    Related
    ENSP00000482749.1, ENST00000621083.4
    Conserved Domains (4) summary
    smart00349
    Location:23 → 83
    KRAB; krueppel associated box
    COG5048
    Location:406 → 779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342 → 363
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001289167.2 → NP_001276096.1  zinc finger protein 227 isoform b

    See identical proteins and their annotated locations for NP_001276096.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK316048, AL833012, DA494064
    Consensus CDS
    CCDS74388.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:271 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001289168.2 → NP_001276097.1  zinc finger protein 227 isoform b

    See identical proteins and their annotated locations for NP_001276097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK299266, AL833012, DA494064
    Consensus CDS
    CCDS74388.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Related
    ENSP00000467577.1, ENST00000589005.5
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:271 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001289169.2 → NP_001276098.1  zinc finger protein 227 isoform b

    See identical proteins and their annotated locations for NP_001276098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK092253, AL833012, DA494064, DA929840
    Consensus CDS
    CCDS74388.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Related
    ENSP00000375823.2, ENST00000391961.6
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:271 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001289170.2 → NP_001276099.1  zinc finger protein 227 isoform c

    See identical proteins and their annotated locations for NP_001276099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AK092253, AK300576, AL833012, DA494064
    UniProtKB/TrEMBL
    B7Z6M2
    Conserved Domains (3) summary
    COG5048
    Location:243 → 627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456 → 480
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001289171.2 → NP_001276100.1  zinc finger protein 227 isoform c

    See identical proteins and their annotated locations for NP_001276100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in its 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AL833012, DA494064, DC341721
    UniProtKB/TrEMBL
    B7Z6M2
    Conserved Domains (3) summary
    COG5048
    Location:243 → 627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456 → 480
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001289172.2 → NP_001276101.1  zinc finger protein 227 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL833012, DA494064, DA514267
    UniProtKB/TrEMBL
    Q658S5
    Conserved Domains (3) summary
    COG5048
    Location:225 → 609
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:425 → 445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:438 → 462
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001289173.2 → NP_001276102.1  zinc finger protein 227 isoform e

    See identical proteins and their annotated locations for NP_001276102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in its 5' UTR, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AL833012, BU153285, DA494064
    UniProtKB/TrEMBL
    Q658S5
    Conserved Domains (5) summary
    smart00349
    Location:23 → 65
    KRAB; krueppel associated box
    COG5048
    Location:294 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 62
    KRAB; KRAB box
    pfam13465
    Location:507 → 531
    zf-H2C2_2; Zinc-finger double domain

  9. NM_182490.3 → NP_872296.1  zinc finger protein 227 isoform a

    See identical proteins and their annotated locations for NP_872296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL833012, BC047570, DA494064
    Consensus CDS
    CCDS12636.1
    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6
    Related
    ENSP00000321049.6, ENST00000313040.12
    Conserved Domains (4) summary
    smart00349
    Location:23 → 83
    KRAB; krueppel associated box
    COG5048
    Location:406 → 779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342 → 363
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44207547..44237268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439377.1 → XP_047295333.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6

  2. XM_047439383.1 → XP_047295339.1  zinc finger protein 227 isoform X3

  3. XM_011527289.3 → XP_011525591.1  zinc finger protein 227 isoform X1

    See identical proteins and their annotated locations for XP_011525591.1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:23 → 83
    KRAB; krueppel associated box
    COG5048
    Location:406 → 779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342 → 363
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047439382.1 → XP_047295338.1  zinc finger protein 227 isoform X3

  5. XM_017027266.2 → XP_016882755.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:23 → 83
    KRAB; krueppel associated box
    COG5048
    Location:406 → 779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342 → 363
    zf-H2C2_2; Zinc-finger double domain

  6. XM_047439380.1 → XP_047295336.1  zinc finger protein 227 isoform X2

  7. XM_005259232.4 → XP_005259289.1  zinc finger protein 227 isoform X1

    See identical proteins and their annotated locations for XP_005259289.1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:23 → 83
    KRAB; krueppel associated box
    COG5048
    Location:406 → 779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342 → 363
    zf-H2C2_2; Zinc-finger double domain

  8. XM_047439379.1 → XP_047295335.1  zinc finger protein 227 isoform X2

  9. XM_017027267.2 → XP_016882756.1  zinc finger protein 227 isoform X3

    Conserved Domains (5) summary
    smart00349
    Location:23 → 65
    KRAB; krueppel associated box
    COG5048
    Location:294 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 62
    KRAB; KRAB box
    pfam13465
    Location:507 → 531
    zf-H2C2_2; Zinc-finger double domain

  10. XM_047439378.1 → XP_047295334.1  zinc finger protein 227 isoform X2

  11. XM_047439381.1 → XP_047295337.1  zinc finger protein 227 isoform X3

  12. XM_011527290.1 → XP_011525592.1  zinc finger protein 227 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:23 → 76
    KRAB; krueppel associated box
    COG5048
    Location:300 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:515 → 535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 62
    KRAB; KRAB box
    pfam13465
    Location:528 → 552
    zf-H2C2_2; Zinc-finger double domain

  13. XM_006723371.1 → XP_006723434.1  zinc finger protein 227 isoform X3

    See identical proteins and their annotated locations for XP_006723434.1

    Conserved Domains (5) summary
    smart00349
    Location:23 → 65
    KRAB; krueppel associated box
    COG5048
    Location:294 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 62
    KRAB; KRAB box
    pfam13465
    Location:507 → 531
    zf-H2C2_2; Zinc-finger double domain

  14. XM_047439384.1 → XP_047295340.1  zinc finger protein 227 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    47030346..47060129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322037.1 → XP_054178012.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6

  2. XM_054322047.1 → XP_054178022.1  zinc finger protein 227 isoform X3

  3. XM_054322048.1 → XP_054178023.1  zinc finger protein 227 isoform X3

  4. XM_054322039.1 → XP_054178014.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6

  5. XM_054322041.1 → XP_054178016.1  zinc finger protein 227 isoform X2

  6. XM_054322045.1 → XP_054178020.1  zinc finger protein 227 isoform X3

  7. XM_054322040.1 → XP_054178015.1  zinc finger protein 227 isoform X2

  8. XM_054322044.1 → XP_054178019.1  zinc finger protein 227 isoform X3

  9. XM_054322042.1 → XP_054178017.1  zinc finger protein 227 isoform X2

  10. XM_054322036.1 → XP_054178011.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6

  11. XM_054322038.1 → XP_054178013.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    B3KRU7, B7Z5P9, Q86WZ6

  12. XM_054322046.1 → XP_054178021.1  zinc finger protein 227 isoform X3

  13. XM_054322043.1 → XP_054178018.1  zinc finger protein 227 isoform X2

  14. XM_054322049.1 → XP_054178024.1  zinc finger protein 227 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WZ6.1 GenPept UniProtKB/Swiss-Prot:Q86WZ6

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