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bop1 BOP1 ribosomal biogenesis factor [ Danio rerio (zebrafish) ]

Gene ID: 777627, updated on 28-Oct-2024

Summary

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Official Symbol
bop1provided by ZNC
Official Full Name
BOP1 ribosomal biogenesis factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-109
See related
Ensembl:ENSDARG00000063627 AllianceGenome:ZFIN:ZDB-GENE-030219-109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
id:ibd1283; zgc:154135; si:ch211-251g8.2; si:ch211-251g8.4
Summary
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of cell cycle. Predicted to act upstream of or within rRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Is expressed in head; immature eye; midbrain hindbrain boundary; optic tectum; and somite. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See bop1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (2929770..3056068, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (2989475..3115150, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene exosome component 7 Neighboring gene HGH1 homolog (S. cerevisiae) Neighboring gene scleraxis bHLH transcription factor a Neighboring gene si:ch211-80h18.1 Neighboring gene heat shock transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Chakraborty A, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29225165
  2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PeBoW complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosome biogenesis protein bop1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077735.2 → NP_001071203.1  ribosome biogenesis protein bop1

    See identical proteins and their annotated locations for NP_001071203.1

    Status: VALIDATED

    Source sequence(s)
    BX255894
    UniProtKB/Swiss-Prot
    A0JMQ0, Q1LXV3
    Related
    ENSDARP00000120969.3, ENSDART00000137020.5
    Conserved Domains (4) summary
    COG2319
    Location:432 → 776
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:438 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08145
    Location:174 → 432
    BOP1NT; BOP1NT (NUC169) domain
    sd00039
    Location:447 → 483
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    2929770..3056068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JMQ0.1 GenPept UniProtKB/Swiss-Prot:A0JMQ0

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