U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

otud7b OTU deubiquitinase 7B [ Danio rerio (zebrafish) ]

Gene ID: 777637, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
otud7bprovided by ZNC
Official Full Name
OTU deubiquitinase 7Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060616-1
See related
Ensembl:ENSDARG00000017220 AllianceGenome:ZFIN:ZDB-GENE-060616-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
za20d1; zgc:152772
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within Notch signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See otud7b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45930940..45982662)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45964239..46017279)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1b Neighboring gene RNA binding motif protein 8A Neighboring gene antifreeze protein type IV Neighboring gene myotubularin related protein 11 Neighboring gene uncharacterized LOC137487856

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
OTU domain-containing protein 7B
Names
OTU domain containing 7B
zinc finger, A20 domain containing 1
NP_001071212.1
XP_005158443.1
XP_005158444.1
XP_005158446.1
XP_021322432.1
XP_068070120.1
XP_068070121.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077744.1 → NP_001071212.1  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001071212.1

    Status: PROVISIONAL

    Source sequence(s)
    BC125816
    UniProtKB/TrEMBL
    A0JMB7
    Related
    ENSDARP00000041810.6, ENSDART00000041811.8
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:878 → 902
    zf-A20; A20-like zinc finger
    cl19932
    Location:183 → 350
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    45930940..45982662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158386.5 → XP_005158443.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/TrEMBL
    A0A8M2B591
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:881 → 905
    zf-A20; A20-like zinc finger
    cl19932
    Location:184 → 351
    OTU; OTU-like cysteine protease

  2. XM_021466757.2 → XP_021322432.1  OTU domain-containing protein 7B isoform X3

    UniProtKB/TrEMBL
    A0A8M9NZE1
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:880 → 904
    zf-A20; A20-like zinc finger
    cl19932
    Location:184 → 351
    OTU; OTU-like cysteine protease

  3. XM_005158389.5 → XP_005158446.1  OTU domain-containing protein 7B isoform X4

    UniProtKB/TrEMBL
    A0A8M2B4T1
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:879 → 903
    zf-A20; A20-like zinc finger
    cl19932
    Location:184 → 351
    OTU; OTU-like cysteine protease

  4. XM_068214020.1 → XP_068070121.1  OTU domain-containing protein 7B isoform X6

  5. XM_005158387.5 → XP_005158444.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/TrEMBL
    A0A8M2B4S2
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:880 → 904
    zf-A20; A20-like zinc finger
    cl19932
    Location:183 → 350
    OTU; OTU-like cysteine protease

  6. XM_068214019.1 → XP_068070120.1  OTU domain-containing protein 7B isoform X5

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools