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zranb1b zinc finger, RAN-binding domain containing 1b [ Danio rerio (zebrafish) ]

Gene ID: 777720, updated on 2-Nov-2024

Summary

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Official Symbol
zranb1bprovided by ZNC
Official Full Name
zinc finger, RAN-binding domain containing 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061110-94
See related
Ensembl:ENSDARG00000063190 AllianceGenome:ZFIN:ZDB-GENE-061110-94
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zranb1; zgc:154177
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within brain development and central nervous system morphogenesis. Predicted to be active in cytoplasm and nucleus. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See zranb1b in Genome Data Viewer
Location:
chromosome: 17
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (8949196..8985240, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (8792023..8828508, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488035 Neighboring gene proteasome 26S subunit, ATPase 1a Neighboring gene A kinase (PRKA) anchor protein 6 Neighboring gene neuronal PAS domain protein 3 Neighboring gene uncharacterized LOC108179743

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of inter-organ vascular network: vessels bridging between organs. Omae M, et al. PLoS One, 2013. PMID 23799039, Free PMC Article
  2. Zebrafish Nk-lysins: First insights about their cellular and functional diversification. Pereiro P, et al. Dev Comp Immunol, 2015 Jul. PMID 25813149
  3. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
  4. New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Tseng LC, et al. PLoS One, 2014. PMID 24714733, Free PMC Article
  5. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K29-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K33-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ubiquitin thioesterase zranb1-B
Names
Ubiquitin thioesterase zranb1
Zinc finger Ran-binding domain-containing protein 1
trabid c
zinc finger Ran-binding domain-containing protein 1-B
zinc finger, RAN-binding domain containing 1
NP_001071236.1
XP_005158652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077768.1 → NP_001071236.1  ubiquitin thioesterase zranb1-B

    See identical proteins and their annotated locations for NP_001071236.1

    Status: PROVISIONAL

    Source sequence(s)
    BC125972
    UniProtKB/Swiss-Prot
    A0JMQ9
    Related
    ENSDARP00000086546.4, ENSDART00000092113.5
    Conserved Domains (3) summary
    smart00547
    Location:156 → 178
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:86 → 105
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:446 → 594
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    8949196..8985240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158595.5 → XP_005158652.1  ubiquitin thioesterase zranb1-B isoform X1

    See identical proteins and their annotated locations for XP_005158652.1

    UniProtKB/Swiss-Prot
    A0JMQ9
    Conserved Domains (3) summary
    smart00547
    Location:156 → 178
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:86 → 105
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:446 → 594
    OTU; OTU-like cysteine protease

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394977.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    215472..245111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JMQ9.1 GenPept UniProtKB/Swiss-Prot:A0JMQ9

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