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kank1a KN motif and ankyrin repeat domains 1a [ Danio rerio (zebrafish) ]

Gene ID: 777729, updated on 17-Sep-2024

Summary

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Official Symbol
kank1aprovided by ZNC
Official Full Name
KN motif and ankyrin repeat domains 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-215
See related
Ensembl:ENSDARG00000060102 AllianceGenome:ZFIN:ZDB-GENE-060526-215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kank1; wu:fc93h12; zgc:153166; si:dkey-146l2.1
Summary
Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including fin; lateral plate mesoderm; notochord; optic vesicle; and otic placode. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See kank1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (44846363..44941009)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (44246212..44340759)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene fructose-1,6-bisphosphatase 2 Neighboring gene fructose-1,6-bisphosphatase 1a Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene doublesex and mab-3 related transcription factor 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors. Cui Z, et al. Sci Rep, 2017 Jan 9. PMID 28067315, Free PMC Article
  2. Mitochondrial Dysfunction, Disruption of F-Actin Polymerization, and Transcriptomic Alterations in Zebrafish Larvae Exposed to Trichloroethylene. Wirbisky SE, et al. Chem Res Toxicol, 2016 Feb 15. PMID 26745549
  3. Sex dimorphic expression of five dmrt genes identified in the Atlantic cod genome. The fish-specific dmrt2b diverged from dmrt2a before the fish whole-genome duplication. Johnsen H, et al. Gene, 2012 Sep 1. PMID 22749781
  4. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Boggetti B, et al. Dev Biol, 2012 May 1. PMID 22387208
  5. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 1a
Names
KN motif and ankyrin repeat domains 1
ankrd15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365257.1 → NP_001352186.1  KN motif and ankyrin repeat domain-containing protein 1a

    Status: VALIDATED

    Source sequence(s)
    CR388096
    UniProtKB/TrEMBL
    A0A8M1RQY7, E9QCJ6
    Related
    ENSDARP00000078805.5, ENSDART00000084370.7
    Conserved Domains (4) summary
    cd00204
    Location:1113 → 1244
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1118 → 1150
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:21 → 59
    KN_motif; KN motif
    pfam12796
    Location:1228 → 1282
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    44846363..44941009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165446.5 → XP_005165503.1  KN motif and ankyrin repeat domain-containing protein 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCU3
    Related
    ENSDARP00000145782.1, ENSDART00000193822.1
    Conserved Domains (3) summary
    cd00204
    Location:965 → 1096
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:970 → 1002
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1080 → 1134
    Ank_2; Ankyrin repeats (3 copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077776.1: Suppressed sequence

    Description
    NM_001077776.1: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein
Heading Accession and Version

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