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nup98 nucleoporin 98 and 96 precursor [ Danio rerio (zebrafish) ]

Gene ID: 777756, updated on 28-Oct-2024

Summary

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Official Symbol
nup98provided by ZNC
Official Full Name
nucleoporin 98 and 96 precursorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1180
See related
Ensembl:ENSDARG00000074955 AllianceGenome:ZFIN:ZDB-GENE-040426-1180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63593; im:7151238; zgc:113968
Summary
Predicted to enable RNA binding activity and nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within enteric nervous system development. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore cytoplasmic filaments. Is expressed in central nervous system and intestine. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See nup98 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40354781..40398640, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40331228..40375135, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene odorant receptor, family 6, subfamily AT, member 1 Neighboring gene neuronal acetylcholine receptor subunit alpha-10 Neighboring gene uncharacterized LOC100534731 Neighboring gene small nucleolar RNA SNORD65 Neighboring gene small nucleolar RNA SNORD65

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Role of a novel zebrafish nup98 during embryonic development. Fung TK, et al. Exp Hematol, 2010 Nov. PMID 20696206
  2. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Gui H, et al. Genome Biol, 2017 Mar 8. PMID 28274275, Free PMC Article
  3. Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Henry TB, et al. Environ Health Perspect, 2007 Jul. PMID 17637923, Free PMC Article
  4. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC63593, MGC173990

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere tethering at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore cytoplasmic filaments IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup98-Nup96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200685.2 → NP_956979.2  nuclear pore complex protein Nup98-Nup96

    Status: VALIDATED

    Source sequence(s)
    CR847523
    UniProtKB/TrEMBL
    A0A8M1PHK6, E7F981
    Related
    ENSDARP00000110413.3, ENSDART00000130950.3
    Conserved Domains (3) summary
    pfam04096
    Location:741 → 881
    Nucleoporin2; Nucleoporin autopeptidase
    pfam12110
    Location:1333 → 1626
    Nup96; Nuclear protein 96
    pfam13634
    Location:39 → 133
    Nucleoporin_FG; Nucleoporin FG repeat region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    40354781..40398640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161439.5 → XP_005161496.1  nuclear pore complex protein Nup98-Nup96 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IAQ8, A0A8M2B8E5
    Related
    ENSDARP00000131290.2, ENSDART00000162500.2
    Conserved Domains (3) summary
    pfam04096
    Location:734 → 874
    Nucleoporin2; Nucleoporin autopeptidase
    pfam12110
    Location:1326 → 1619
    Nup96; Nuclear protein 96
    pfam13634
    Location:39 → 133
    Nucleoporin_FG; Nucleoporin FG repeat region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077797.1: Suppressed sequence

    Description
    NM_001077797.1: This RefSeq was permanently suppressed because it was based on chimeric sequence.
Nucleotide Protein Strain
Heading Accession and Version

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