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Rictor RPTOR independent companion of MTOR, complex 2 [ Mus musculus (house mouse) ]

Gene ID: 78757, updated on 29-Oct-2024

Summary

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Official Symbol
Rictorprovided by MGI
Official Full Name
RPTOR independent companion of MTOR, complex 2provided by MGI
Primary source
MGI:MGI:1926007
See related
Ensembl:ENSMUSG00000050310 AllianceGenome:MGI:1926007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AVO3; 4921505C17Rik; 6030405M08Rik; D530039E11Rik
Summary
Enables ribosome binding activity. Involved in embryo development; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of protein phosphorylation. Acts upstream of or within several processes, including positive regulation of actin filament polymerization; regulation of establishment of cell polarity; and regulation of protein phosphorylation. Part of TORC2 complex. Is expressed in early conceptus; embryo; and oocyte. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 3.9), cerebellum adult (RPKM 2.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rictor in Genome Data Viewer
Location:
15 A1; 15 3.25 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6737827..6829882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6708349..6800401)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 9 Neighboring gene STARR-seq mESC enhancer starr_37861 Neighboring gene FYN binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_37865 Neighboring gene predicted gene 2245 Neighboring gene STARR-seq mESC enhancer starr_37866 Neighboring gene prohibitin pseudogene Neighboring gene STARR-seq mESC enhancer starr_37870 Neighboring gene predicted gene, 53882 Neighboring gene oncostatin M receptor Neighboring gene STARR-seq mESC enhancer starr_37871 Neighboring gene STARR-seq mESC enhancer starr_37872 Neighboring gene predicted gene, 41261 Neighboring gene predicted gene, 30559

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. mTORC2 negatively controls the maturation process of medullary thymic epithelial cells by inhibiting the LTβR/RANK-NF-κB axis. Liang Z, et al. J Cell Physiol, 2021 Jun. PMID 33269476
  2. Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers. Morrison Joly M, et al. Cancer Res, 2016 Aug 15. PMID 27197158, Free PMC Article
  3. Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity. Wang Y, et al. Clin Cancer Res, 2022 Jan 15. PMID 34728526, Free PMC Article
  4. Rictor/mTORC2 loss in osteoblasts impairs bone mass and strength. Liu DM, et al. Bone, 2016 Sep. PMID 27262777
  5. Rictor has a pivotal role in maintaining quiescence as well as stemness of leukemia stem cells in MLL-driven leukemia. Fang Y, et al. Leukemia, 2017 Feb. PMID 27499138

See all (287) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis.
    Title: Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis.
  2. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
  3. Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.
    Title: Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.
  4. miR-582 negatively regulates pre-B cell proliferation and survival through targeting Hif1alpha and Rictor.
    Title: miR-582 negatively regulates pre-B cell proliferation and survival through targeting Hif1α and Rictor.
  5. Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.
    Title: Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.
  6. Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
    Title: Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
  7. Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43.
    Title: Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43.
  8. Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
    Title: Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
  9. Enhancing Acsl4 in absence of mTORC2/Rictor drove beta-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production.
    Title: Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production.
  10. Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts.
    Title: Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rapamycin-insensitive companion of mTOR
Names
AVO3 homolog
mAVO3
protein pianissimo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030168.3 → NP_084444.3  rapamycin-insensitive companion of mTOR

    See identical proteins and their annotated locations for NP_084444.3

    Status: VALIDATED

    Source sequence(s)
    AI854883, AK036149, AK173326, BC120903
    Consensus CDS
    CCDS37032.1
    UniProtKB/Swiss-Prot
    E9QPE0, Q0VAV4, Q69Z40, Q6PDL2, Q6QI06, Q6RI74, Q8BPH9, Q8CBF2
    Related
    ENSMUSP00000051809.7, ENSMUST00000061656.8
    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:58 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1084 → 1187
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 991
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    6737827..6829882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520003.2 → XP_006520066.1  rapamycin-insensitive companion of mTOR isoform X1

    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:60 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1085 → 1187
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 988
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  2. XM_036159639.1 → XP_036015532.1  rapamycin-insensitive companion of mTOR isoform X2

    Conserved Domains (5) summary
    pfam14663
    Location:465 → 571
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:14 → 155
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:803 → 905
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:355 → 458
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:640 → 709
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

RNA

  1. XR_004938879.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6QI06.2 GenPept UniProtKB/Swiss-Prot:Q6QI06

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