Wsb1 WD repeat and SOCS box-containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wsb1provided by MGI
Official Full Name: WD repeat and SOCS box-containing 1provided by MGI
Primary source: MGI:MGI:1926139
See related: Ensembl:ENSMUSG00000017677 AllianceGenome:MGI:1926139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110056B13Rik; 2700038M07Rik
Summary: Enables ubiquitin protein ligase activity. Involved in protein K27-linked ubiquitination. Acts upstream of or within protein aggregate center assembly. Located in cytoplasm. Is expressed in nervous system and neural retina. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 127.9), CNS E14 (RPKM 125.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (79130208..79145521, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (79239382..79254709, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis.
Title: WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis.
WSB1 is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.
Title: WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.
WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2).
Title: The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68596 (e-PCR)
- UniSTS:85296

D11Bhm103 (e-PCR), detects polymorphism
- UniSTS:141538

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein K27-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein aggregate center assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein aggregate center assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat and SOCS box-containing protein 1

Names: WD-40-repeat-containing protein with a SOCS box 1; WSB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042565.3 → NP_001036030.1 WD repeat and SOCS box-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_001036030.1

Status: VALIDATED

Source sequence(s)

AI644176, AK048511, BG069536

UniProtKB/TrEMBL

Q8C841, Q8VE81

Related

ENSMUST00000150416.8

Conserved Domains (3) summary

sd00039
Location:17 → 57

7WD40; WD40 repeat [structural motif]

cl02533
Location:140 → 178

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl29593
Location:1 → 146

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_019653.3 → NP_062627.3 WD repeat and SOCS box-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_062627.3

Status: VALIDATED

Source sequence(s)

AK167394, BB431254, BY097910

Consensus CDS

CCDS25118.1

UniProtKB/Swiss-Prot

O54927

UniProtKB/TrEMBL

Q3TFQ2, Q3TIA1, Q3U7R9, Q7TMU2

Related

ENSMUSP00000017821.6, ENSMUST00000017821.12

Conserved Domains (4) summary

COG2319
Location:139 → 382

WD40; WD40 repeat [General function prediction only]

cd00200
Location:135 → 388

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:174 → 212

7WD40; WD40 repeat [structural motif]

cl02533
Location:382 → 420

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

79130208..79145521 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157103.1 → XP_036012996.1 WD repeat and SOCS box-containing protein 1 isoform X1

UniProtKB/TrEMBL

Q8C841, Q8VE81

Conserved Domains (3) summary

sd00039
Location:17 → 57

7WD40; WD40 repeat [structural motif]

cl02533
Location:140 → 178

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl29593
Location:1 → 146

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...