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GID4 GID complex subunit 4 homolog [ Homo sapiens (human) ]

Gene ID: 79018, updated on 4-Jan-2025

Summary

Official Symbol
GID4provided by HGNC
Official Full Name
GID complex subunit 4 homologprovided by HGNC
Primary source
HGNC:HGNC:28453
See related
Ensembl:ENSG00000141034 MIM:617699; AllianceGenome:HGNC:28453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VID2; VID24; C17orf39
Summary
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 9.8), esophagus (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See GID4 in Genome Data Viewer
Location:
17p11.2; 17p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18039408..18068405)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (17986211..18015201)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17942722..17971719)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 6800 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17925691-17925854 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991145-17991646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991647-17992146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18010366-18011013 Neighboring gene uncharacterized LOC105371566 Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene myosin XVA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18038431-18039424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18039425-18040418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18045565-18046530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18046531-18047495 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC3048

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol  
part_of ubiquitin ligase complex PubMed 

General protein information

Preferred Names
glucose-induced degradation protein 4 homolog
Names
GID complex subunit 4, VID24 homolog
vacuolar import and degradation 24
vacuolar import and degradation protein 24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411057.1NP_001397986.1  glucose-induced degradation protein 4 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087164
    Consensus CDS
    CCDS92267.1
    UniProtKB/TrEMBL
    K4DI96
    Related
    ENSP00000365523.3, ENST00000376345.3
  2. NM_024052.5NP_076957.3  glucose-induced degradation protein 4 homolog isoform 1

    See identical proteins and their annotated locations for NP_076957.3

    Status: VALIDATED

    Source sequence(s)
    AC087164, AK127580, BC041829
    Consensus CDS
    CCDS11190.1
    UniProtKB/Swiss-Prot
    Q8IVV7, Q8TEB5, Q9BW50
    Related
    ENSP00000268719.4, ENST00000268719.9
    Conserved Domains (1) summary
    pfam09783
    Location:121289
    Vac_ImportDeg; Vacuolar import and degradation protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18039408..18068405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256800.2XP_005256857.1  glucose-induced degradation protein 4 homolog isoform X1

    Conserved Domains (1) summary
    pfam09783
    Location:121236
    Vac_ImportDeg; Vacuolar import and degradation protein
  2. XM_011524008.2XP_011522310.1  glucose-induced degradation protein 4 homolog isoform X2

    Conserved Domains (1) summary
    pfam09783
    Location:122236
    Vac_ImportDeg; Vacuolar import and degradation protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    17986211..18015201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317124.1XP_054173099.1  glucose-induced degradation protein 4 homolog isoform X1

  2. XM_054317125.1XP_054173100.1  glucose-induced degradation protein 4 homolog isoform X2

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