vps8 VPS8 subunit of CORVET complex [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vps8provided by ZNC
Official Full Name: VPS8 subunit of CORVET complexprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-348
See related: Ensembl:ENSDARG00000060477 AllianceGenome:ZFIN:ZDB-GENE-060503-348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7166005; zgc:158695; si:dkey-24b15.1
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in endosomal vesicle fusion and protein targeting to vacuole. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be part of CORVET complex and HOPS complex. Predicted to be active in early endosome and late endosome. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (30083575..30310689)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (29279637..29506755)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fj38h08.x1 (e-PCR)
- UniSTS:199271

G46387 (e-PCR)
- UniSTS:107189

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosomal vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein targeting to vacuole	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CORVET complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vacuolar protein sorting-associated protein 8 homolog

Names: vacuolar protein sorting 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080616.2 → NP_001074085.2 vacuolar protein sorting-associated protein 8 homolog

Status: VALIDATED

Source sequence(s)

BX005120, BX255890, CU468285

UniProtKB/TrEMBL

A0A8N1TQD8, F1QQ05

Related

ENSDARP00000117166.1, ENSDART00000143639.3

Conserved Domains (5) summary

pfam00637
Location:957 → 1076

Clathrin; Region in Clathrin and VPS

pfam12816
Location:586 → 768

Vps8; Golgi CORVET complex core vacuolar protein 8

sd00039
Location:174 → 211

7WD40; WD40 repeat [structural motif]

cl02567
Location:133 → 279

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22851
Location:1243 → 1294

PHD_SF; PHD finger superfamily