sacm1lb SAC1 like phosphatidylinositide phosphatase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sacm1lbprovided by ZNC
Official Full Name: SAC1 like phosphatidylinositide phosphatase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-542
See related: Ensembl:ENSDARG00000059806 AllianceGenome:ZFIN:ZDB-GENE-070112-542
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SACM1L; fc56f05; sacm1la; wu:fc56f05; zgc:158642
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. A paralog of this gene (sacm1la, GeneID:558940) exists on chromosome 19. [provided by RefSeq, May 2018]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (53603945..53633569)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (53717118..53746742)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-plasma membrane contact site	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol-3-phosphatase SAC1-B

Names: SAC1 suppressor of actin mutations 1-like b; phosphatidylinositide phosphatase SAC1-A; phosphatidylinositide phosphatase SAC1-B; phosphatidylinositol-4-phosphate phosphatase; suppressor of actin mutations 1-like protein A; suppressor of actin mutations 1-like protein B

NP_001074093.2

EC 3.1.3.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080624.2 → NP_001074093.2 phosphatidylinositol-3-phosphatase SAC1-B

Status: REVIEWED

Source sequence(s)

CR759845

UniProtKB/Swiss-Prot

A1L244

UniProtKB/TrEMBL

B2GSY5

Related

ENSDARP00000077948.4, ENSDART00000083513.5

Conserved Domains (1) summary

COG5329
Location:56 → 526

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

53603945..53633569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001357732.1: Suppressed sequence

Description

NM_001357732.1: This RefSeq was removed because currently there is insufficient support for stop codon readthrough in this gene.