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mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 792689, updated on 12-Sep-2024

Summary

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Official Symbol
mlst8provided by ZNC
Official Full Name
MTOR associated protein, LST8 homolog (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6176
See related
Ensembl:ENSDARG00000003167 AllianceGenome:ZFIN:ZDB-GENE-030131-6176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gbl; fi37e04; zgc:55455; zgc:85668; wu:fi37e04
Summary
Predicted to be involved in TOR signaling and regulation of actin cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mlst8 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18543792..18553114)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18421918..18431240)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase B1b Neighboring gene meiosis specific with OB-fold Neighboring gene BRICHOS domain containing 5 Neighboring gene phosphoglycolate phosphatase Neighboring gene zinc finger DHHC-type palmitoyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Cao L, et al. Commun Biol, 2022 Aug 30. PMID 36042265, Free PMC Article
  2. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. Frank DF, et al. PeerJ, 2017. PMID 29201571, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55455, MGC85668

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
target of rapamycin complex subunit lst8
Names
TORC subunit lst8
gable
protein GbetaL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320388.1 → NP_001307317.1  target of rapamycin complex subunit lst8

    Status: VALIDATED

    Source sequence(s)
    CT009714, EH546936, EH568073
    UniProtKB/Swiss-Prot
    Q803V5
    UniProtKB/TrEMBL
    B2GPI2
    Related
    ENSDARP00000118004.1, ENSDART00000148326.3
    Conserved Domains (3) summary
    COG2319
    Location:10 → 320
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:47 → 83
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    18543792..18553114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394835.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    510166..519488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199877.2: Suppressed sequence

    Description
    NM_199877.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q803V5.1 GenPept UniProtKB/Swiss-Prot:Q803V5

Gene LinkOut

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