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ccn4b cellular communication network factor 4b [ Danio rerio (zebrafish) ]

Gene ID: 792714, updated on 12-Sep-2024

Summary

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Official Symbol
ccn4bprovided by ZNC
Official Full Name
cellular communication network factor 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080220-16
See related
Ensembl:ENSDARG00000076685 AllianceGenome:ZFIN:ZDB-GENE-080220-16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wisp1b; zgc:172276
Summary
Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in cell adhesion; negative regulation of cell death; and signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in thyroid follicle. Orthologous to human CCN4 (cellular communication network factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ccn4b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31518783..31525232, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31560520..31567354, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4A3b Neighboring gene N-myc downstream regulated 1b Neighboring gene src-like-adapter Neighboring gene thyroglobulin Neighboring gene PHD finger protein 20 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Temporal and spatial expression of CCN genes in zebrafish. Fernando CA, et al. Dev Dyn, 2010 Jun. PMID 20503371, Free PMC Article
  2. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Khayrullin A, et al. Biochem Biophys Res Commun, 2016 Oct 21. PMID 27671199
  3. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Zhang H, et al. Stem Cells, 2015 Mar. PMID 25420467
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cellular communication network factor 4b
Names
WNT1 inducible signaling pathway protein 1b
zWISP1-c16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113628.1 → NP_001107100.1  cellular communication network factor 4b precursor

    See identical proteins and their annotated locations for NP_001107100.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154630
    UniProtKB/TrEMBL
    A8WG98
    Related
    ENSDARP00000099684.3, ENSDART00000109996.4
    Conserved Domains (4) summary
    smart00209
    Location:208 → 249
    TSP1; Thrombospondin type 1 repeats
    smart00214
    Location:115 → 174
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:41 → 93
    IGFBP; Insulin-like growth factor binding protein
    cl21545
    Location:272 → 335
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    31518783..31525232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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