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rxfp2a relaxin family peptide receptor 2a [ Danio rerio (zebrafish) ]

Gene ID: 792884, updated on 28-Oct-2024

Summary

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Official Symbol
rxfp2aprovided by ZNC
Official Full Name
relaxin family peptide receptor 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1225
See related
Ensembl:ENSDARG00000032820 AllianceGenome:ZFIN:ZDB-GENE-040426-1225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rxfp2; lgr8.1; rxfp2b; zgc:63668
Summary
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in female organism; male organism; ovary; and testis. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Oct 2024]
Annotation information
Note: This record was renamed from rxfp2b to rxfp2a based on PMID:22470432. [11/17/2015] [17 Nov 2015]
Orthologs
all
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Genomic context

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See rxfp2a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (33754608..33867766)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (33811107..33923881)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene beta 3-glucosyltransferase b Neighboring gene uncharacterized LOC101886689 Neighboring gene DNA ligase 1-like Neighboring gene furry homolog b (Drosophila) Neighboring gene uncharacterized LOC103911763 Neighboring gene zygote arrest 1-like Neighboring gene klotho

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors. Yegorov S, et al. PLoS One, 2012. PMID 22470432, Free PMC Article
  2. Expression pattern of zebrafish rxfp2 homologue genes during embryonic development. Donizetti A, et al. J Exp Zool B Mol Dev Evol, 2015 Nov. PMID 26173401
  3. Japanese medaka as a model for studying the relaxin family genes involved in neuroendocrine regulation: Insights from the expression of fish-specific rln3 and insl5 and rxfp3/4-type receptor paralogues. Alnafea H, et al. Mol Cell Endocrinol, 2019 May 1. PMID 30703485
  4. Estrogen-induced inhibition of spermatogenesis in zebrafish is largely reversed by androgen. de Castro Assis LH, et al. J Mol Endocrinol, 2018 May. PMID 29476039
  5. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Good S, et al. Int J Evol Biol, 2012. PMID 23008798, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analyzed the expression pattern of three rxfp2 homologue genes in zebrafish embryonic development
    Title: Expression pattern of zebrafish rxfp2 homologue genes during embryonic development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC63668

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
relaxin receptor 2a
Names
relaxin/insulin-like family peptide receptor 2
relaxin/insulin-like family peptide receptor 2a
relaxin/insulin-like family peptide receptor 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328384.1 → NP_001315313.1  relaxin receptor 2a

    Status: VALIDATED

    Source sequence(s)
    BX569785, CR555290
    UniProtKB/TrEMBL
    A0A0R3P9B9, A0A8M1PA79
    Related
    ENSDARP00000127216.1, ENSDART00000153442.3
    Conserved Domains (4) summary
    cd00112
    Location:42 → 77
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    sd00033
    Location:136 → 159
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:304 → 360
    LRR_8; Leucine rich repeat
    cl21561
    Location:422 → 647
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    33754608..33867766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223827.1 → XP_068079928.1  relaxin receptor 2a isoform X1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394793.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    183480..301348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395291.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    183936..242931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200443.1: Suppressed sequence

    Description
    NM_200443.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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