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CORO7 coronin 7 [ Homo sapiens (human) ]

Gene ID: 79585, updated on 2-Nov-2024

Summary

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Official Symbol
CORO7provided by HGNC
Official Full Name
coronin 7provided by HGNC
Primary source
HGNC:HGNC:26161
See related
Ensembl:ENSG00000262246 MIM:611668; AllianceGenome:HGNC:26161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRN7; POD1; 0610011B16Rik
Summary
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
Expression
Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See CORO7 in Genome Data Viewer
Location:
16p13.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4354542..4416596, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4383717..4445792, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4404543..4466597, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4374751-4375535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4378569-4379569 Neighboring gene GLIS family zinc finger 2 Neighboring gene GLIS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4389543-4390289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4390290-4391035 Neighboring gene CORO7-PAM16 readthrough Neighboring gene MPRA-validated peak2471 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4397350-4397850 Neighboring gene presequence translocase associated motor 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4415328-4415828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4419155-4419654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4421231-4422056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4424664-4425443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4425537-4426318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4426319-4427098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4428659-4429440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4433428-4434269 Neighboring gene vasorin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4440665-4441216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4441217-4441770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4452006-4452742 Neighboring gene uncharacterized LOC124903635 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4499977-4500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4505719-4506689

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. Rybakin V, et al. Cell Mol Life Sci, 2008 Aug. PMID 18581049, Free PMC Article
  2. Implication of coronin 7 in body weight regulation in humans, mice and flies. Eriksson A, et al. BMC Neurosci, 2015 Mar 14. PMID 25887538, Free PMC Article
  3. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. Rybakin V, et al. FEBS Lett, 2004 Aug 27. PMID 15327992
  4. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. Rybakin V, et al. J Biol Chem, 2006 Oct 13. PMID 16905771
  5. Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Bhattacharya K, et al. Sci Rep, 2016 May 4. PMID 27143109, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function
    Title: Implication of coronin 7 in body weight regulation in humans, mice and flies.
  2. Results show that enforced targeting of Crn7 to TGN 9trans-Golgi network) bypasses the requirement of K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi trafficking.
    Title: K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.
  3. Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex.
    Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Sequential events of protein interaction and posttranslational modification result in the membrane targeting of Crn7.
    Title: Molecular mechanism underlying the association of Coronin-7 with Golgi membranes.
  6. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi
    Title: Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi.
  7. role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton
    Title: Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough CORO7-PAM16

Readthrough gene: CORO7-PAM16, Included gene: PAM16

Homology

Clone Names

  • FLJ22021, FLJ44188

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi to endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coronin-7
Names
70 kDa WD repeat tumor rejection antigen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052966.1 RefSeqGene

    Range
    5366..67420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201472.2 → NP_001188401.1  coronin-7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC012676, AK294045, BM671637
    Consensus CDS
    CCDS58417.1
    UniProtKB/TrEMBL
    B4DKU9
    Related
    ENSP00000440460.2, ENST00000537233.6
    Conserved Domains (4) summary
    pfam08953
    Location:5 → 60
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:790 → 834
    WD40_4; Type of WD40 repeat
    sd00039
    Location:486 → 522
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:528 → 686
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001201473.2 → NP_001188402.1  coronin-7 isoform 3

    See identical proteins and their annotated locations for NP_001188402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons that result in a missing in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK296807, BM671637
    Consensus CDS
    CCDS55982.1
    UniProtKB/TrEMBL
    B4DKU9
    Related
    ENSP00000461702.1, ENST00000574025.5
    Conserved Domains (4) summary
    pfam08953
    Location:5 → 60
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:723 → 767
    WD40_4; Type of WD40 repeat
    sd00039
    Location:419 → 455
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:461 → 619
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001351729.2 → NP_001338658.1  coronin-7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK094596, BM671637, DA944874
    UniProtKB/TrEMBL
    B3KSY4, B3KUH7
    Conserved Domains (2) summary
    sd00039
    Location:284 → 320
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:251 → 660
    WD40_4; Type of WD40 repeat

  4. NM_024535.5 → NP_078811.3  coronin-7 isoform 1

    See identical proteins and their annotated locations for NP_078811.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC117291, BM671637, DR155527
    Consensus CDS
    CCDS10513.1
    UniProtKB/Swiss-Prot
    B4DFD6, B4DL18, I3L416, P57737, Q17RK4
    UniProtKB/TrEMBL
    B4DKU9
    Related
    ENSP00000251166.4, ENST00000251166.9
    Conserved Domains (2) summary
    sd00039
    Location:81 → 124
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:471 → 880
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4354542..4416596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    56867..118919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4383717..4445792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57737.2 GenPept UniProtKB/Swiss-Prot:P57737

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