nrg1 neuregulin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrg1provided by ZNC
Official Full Name: neuregulin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050302-113
See related: Ensembl:ENSDARG00000104314 AllianceGenome:ZFIN:ZDB-GENE-050302-113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fm70e01
Summary: Predicted to enable chemorepellent activity and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including enteric nervous system development; fin regeneration; and neurogenesis. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in gut; heart; nervous system; and somite. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebrovascular disease (multiple); neurodegenerative disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (7282824..7472491, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (7325266..7513780, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration.
Title: NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration.
Neuregulin-1 is essential for nerve plexus formation during cardiac maturation.
Title: Neuregulin-1 is essential for nerve plexus formation during cardiac maturation.
Loss of zinc finger protein multitype 1 (Zfpm1) activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation.
Title: The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling.
we observed the activation of Notch signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
Title: In Vivo Visualization of Cardiomyocyte Apicobasal Polarity Reveals Epithelial to Mesenchymal-like Transition during Cardiac Trabeculation.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF-like ligand(s) activates the ErbB2/ErbB4 pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF family member requirements for an evolutionary conserved process.
Title: IgG-Containing Isoforms of Neuregulin-1 Are Dispensable for Cardiac Trabeculation in Zebrafish.
Notch1 activation induces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression
Title: Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish.
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
Title: Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
Title: Neuronal Neuregulin 1 type III directs Schwann cell migration.
NRG1 and PI3K functionally interact with ErbB2 and ErbB3 during regeneration
Title: ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration.
Disc1 and nrg1 function in controlling development of oligodendrocytes and neurones from olig2-expressing precursor cells.
Title: Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

z43433b (e-PCR), detects polymorphism
- UniSTS:238754

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB3 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERBB4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Schwann cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eurydendroid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oligodendrocyte cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-neuregulin-1, membrane-bound isoform

Names: neuregulin 1 type I isoform; neuregulin 1 type II isoform; neuregulin 1 type III isoform; neuregulin1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044911.2 → NP_001038376.2 pro-neuregulin-1, membrane-bound isoform isoform 1

See identical proteins and their annotated locations for NP_001038376.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest protein (isoform 1).

Source sequence(s)

BC163772, BX321906

UniProtKB/TrEMBL

A0A0R4ILU9, B3DK99, B9VQK6

Related

ENSDARP00000134846.1, ENSDART00000167963.2

Conserved Domains (4) summary

PHA03099
Location:131 → 241

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:40 → 129

I-set; Immunoglobulin I-set domain

pfam02158
Location:202 → 587

Neuregulin; Neuregulin family

cl11960
Location:52 → 127

Ig; Immunoglobulin domain
NM_001277084.1 → NP_001264013.1 pro-neuregulin-1, membrane-bound isoform isoform IIa

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform IIa) is longer and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

BX321906, BX537303, CR855879, CU459101

UniProtKB/TrEMBL

A0A0R4IDP7, A0A8M1P3W4

Related

ENSDARP00000132985.1, ENSDART00000167706.2

Conserved Domains (4) summary

PHA03099
Location:257 → 367

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:166 → 255

I-set; Immunoglobulin I-set domain

pfam02158
Location:328 → 713

Neuregulin; Neuregulin family

cl11960
Location:178 → 253

Ig; Immunoglobulin domain
NM_001277085.1 → NP_001264014.1 pro-neuregulin-1, membrane-bound isoform isoform IIb1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform IIb1) is longer and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

BX321906, BX537303, CR855879, CU459101

UniProtKB/TrEMBL

A0A0R4IPH3, A0A8M1NZW6

Related

ENSDARP00000137540.1, ENSDART00000167054.2

Conserved Domains (4) summary

PHA03099
Location:257 → 364

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:166 → 255

I-set; Immunoglobulin I-set domain

pfam02158
Location:325 → 710

Neuregulin; Neuregulin family

cl11960
Location:178 → 253

Ig; Immunoglobulin domain
NM_001277086.1 → NP_001264015.1 pro-neuregulin-1, membrane-bound isoform isoform IIb12

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform IIb12) is longer and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

BX321906, BX537303, CR855879, CU459101

UniProtKB/TrEMBL

A0A0R4IBM0, A0A8M1P469

Related

ENSDARP00000131493.1, ENSDART00000163702.2

Conserved Domains (4) summary

PHA03099
Location:257 → 372

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:166 → 255

I-set; Immunoglobulin I-set domain

pfam02158
Location:333 → 718

Neuregulin; Neuregulin family

cl11960
Location:178 → 253

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

7282824..7472491 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068223831.1 → XP_068079932.1 pro-neuregulin-1, membrane-bound isoform isoform X3
XM_009300426.4 → XP_009298701.1 pro-neuregulin-1, membrane-bound isoform isoform X1

UniProtKB/TrEMBL

A0A8M3B1T9

Conserved Domains (4) summary

PHA03099
Location:257 → 371

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:166 → 255

I-set; Immunoglobulin I-set domain

pfam02158
Location:332 → 717

Neuregulin; Neuregulin family

cl11960
Location:178 → 253

Ig; Immunoglobulin domain
XM_009300563.4 → XP_009298838.1 pro-neuregulin-1, membrane-bound isoform isoform X2

UniProtKB/TrEMBL

A0A8M3B1W6

Conserved Domains (4) summary

PHA03099
Location:257 → 366

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:166 → 255

I-set; Immunoglobulin I-set domain

pfam02158
Location:328 → 712

Neuregulin; Neuregulin family

cl11960
Location:178 → 253

Ig; Immunoglobulin domain
XM_009300806.4 → XP_009299081.1 pro-neuregulin-1, membrane-bound isoform isoform X6

UniProtKB/TrEMBL

A0A1B4Z255

Conserved Domains (4) summary

PHA03099
Location:131 → 246

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:40 → 129

I-set; Immunoglobulin I-set domain

pfam02158
Location:207 → 592

Neuregulin; Neuregulin family

cl11960
Location:52 → 127

Ig; Immunoglobulin domain
XM_009300713.4 → XP_009298988.1 pro-neuregulin-1, membrane-bound isoform isoform X4

UniProtKB/TrEMBL

A0A8M3B955

Conserved Domains (2) summary

PHA03099
Location:202 → 334

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam02158
Location:295 → 680

Neuregulin; Neuregulin family
XM_005155463.5 → XP_005155520.1 pro-neuregulin-1, membrane-bound isoform isoform X5

UniProtKB/TrEMBL

A0A0R4IFE6, A0A8M2B2C3

Related

ENSDARP00000132632.1, ENSDART00000168885.2

Conserved Domains (2) summary

PHA03099
Location:202 → 329

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam02158
Location:290 → 675

Neuregulin; Neuregulin family