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ndst2b N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b [ Danio rerio (zebrafish) ]

Gene ID: 798226, updated on 2-Nov-2024

Summary

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Official Symbol
ndst2bprovided by ZNC
Official Full Name
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100430-2
See related
Ensembl:ENSDARG00000060678 AllianceGenome:ZFIN:ZDB-GENE-100430-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ndst2
Summary
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and hydrolase activity. Predicted to be involved in heparin biosynthetic process. Predicted to be located in membrane. Is expressed in alar plate midbrain region; brain; midbrain neural rod; optic tectum; and rhombomere. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ndst2b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (35203144..35341611)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (35101980..35238824)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch73-127m5.2 Neighboring gene si:ch73-127m5.1 Neighboring gene cannabinoid receptor 2-like Neighboring gene calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 Neighboring gene SEC24 homolog C, COPII coat complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Glycome and transcriptome regulation of vasculogenesis. Harfouche R, et al. Circulation, 2009 Nov 10. PMID 19858418, Free PMC Article
  2. Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation. Anderson RA, et al. Gene Expr Patterns, 2023 Mar. PMID 36503154, Free PMC Article
  3. The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation. Filipek-Górniok B, et al. PLoS One, 2015. PMID 25767878, Free PMC Article
  4. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
XP_021336066.1
XP_068080907.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    35203144..35341611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480391.2 → XP_021336066.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

    UniProtKB/TrEMBL
    A0A8M2B2F8, E7F995, U3JAI5
    Related
    ENSDARP00000127253.1, ENSDART00000153022.3
    Conserved Domains (2) summary
    pfam00685
    Location:613 → 864
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:25 → 524
    HSNSD; heparan sulfate-N-deacetylase

  2. XM_068224806.1 → XP_068080907.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

    Related
    ENSDARP00000143988.1, ENSDART00000178663.2
Nucleotide Protein
Heading Accession and Version

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