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spns1 SPNS lysolipid transporter 1, lysophospholipid [ Danio rerio (zebrafish) ]

Gene ID: 799873, updated on 28-Oct-2024

Summary

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Official Symbol
spns1provided by ZNC
Official Full Name
SPNS lysolipid transporter 1, lysophospholipidprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020228-1
See related
Ensembl:ENSDARG00000011925 AllianceGenome:ZFIN:ZDB-GENE-020228-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nrs; spinl; wu:fb95b12; wu:fi37e11; etID64740.3
Summary
Predicted to enable transmembrane transporter activity. Acts upstream of or within autophagosome maturation and cellular senescence. Predicted to be located in lysosomal membrane. Predicted to be active in membrane. Is expressed in yolk syncytial layer. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See spns1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15455319..15475117, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15305519..15325332, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ataxin 2-like Neighboring gene si:dkey-56d12.4 Neighboring gene linker for activation of T cells Neighboring gene nuclear factor of activated T cells 2 interacting protein Neighboring gene SAGA complex associated factor 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis. Young RM, et al. Dev Dyn, 2002 Mar. PMID 11836794
  2. Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage. He M, et al. Proc Natl Acad Sci U S A, 2022 Oct 4. PMID 36161949, Free PMC Article
  3. Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish. Khan A, et al. J Cell Mol Med, 2021 Jan. PMID 33277797, Free PMC Article
  4. Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Sasaki T, et al. Autophagy, 2017 Feb. PMID 27875093, Free PMC Article
  5. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. Sasaki T, et al. PLoS Genet, 2014 Jun. PMID 24967584, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.
    Title: Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.
  2. Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.
    Title: Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.
  3. Spns1 and the v-ATPase orchestrate proper autolysosomal biogenesis with optimal acidification that is critically linked to developmental senescence and survival.
    Title: Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.
  4. Spns1 operates during autophagy and senescence differentially with Beclin 1 and p53.
    Title: Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency.
  5. Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
    Title: Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC55239

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular senescence IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein spinster homolog 1
Names
not really started
protein not really started
spinster homolog 1
spinster-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153663.2 → NP_705949.2  protein spinster homolog 1

    Status: VALIDATED

    Source sequence(s)
    BX784026, CF999294, CK027241, CK029141, EH478886, EH585608, EH595239
    UniProtKB/Swiss-Prot
    Q7ZU13, Q8UVB7
    UniProtKB/TrEMBL
    A0A8M2BB36, G1K2F4
    Related
    ENSDARP00000009970.7, ENSDART00000025324.9
    Conserved Domains (2) summary
    cd06174
    Location:49 → 462
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:52 → 403
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    15455319..15475117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163832.5 → XP_005163889.1  protein spinster homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7ZU13, Q8UVB7
    UniProtKB/TrEMBL
    A0A8M2BB36, G1K2F4
    Related
    ENSDARP00000151373.1, ENSDART00000185302.1
    Conserved Domains (2) summary
    cd06174
    Location:49 → 462
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:52 → 403
    MFS_1; Major Facilitator Superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394524.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    110201..130131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZU13.1 GenPept UniProtKB/Swiss-Prot:Q7ZU13

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