pde9aa phosphodiesterase 9aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pde9aaprovided by ZNC
Official Full Name: phosphodiesterase 9aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-130920-1
See related: Ensembl:ENSDARG00000060280 AllianceGenome:ZFIN:ZDB-GENE-130920-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pde9a; si:ch211-140m22.4
Summary: Predicted to enable 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP catabolic process and cGMP-mediated signaling. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (19421635..19477264)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (19610789..19666390)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual roles of PDE9a in meiotic maturation of zebrafish oocytes.
Title: Dual roles of PDE9a in meiotic maturation of zebrafish oocytes.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Names: phosphodiesterase 9A

XP_009302928.1

EC 3.1.4.35

XP_009302929.1

EC 3.1.4.35

XP_021334564.1

EC 3.1.4.35

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

19421635..19477264

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009304653.3 → XP_009302928.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

See identical proteins and their annotated locations for XP_009302928.1

UniProtKB/TrEMBL

A0A8M3AW03, F1R112

Related

ENSDARP00000079206.5, ENSDART00000084771.6

Conserved Domains (1) summary

pfam00233
Location:242 → 472

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_009304654.3 → XP_009302929.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

See identical proteins and their annotated locations for XP_009302929.1

UniProtKB/TrEMBL

A0A8M3AW03, F1R112

Related

ENSDARP00000131926.1, ENSDART00000159090.2

Conserved Domains (1) summary

pfam00233
Location:242 → 472

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_021478889.1 → XP_021334564.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

UniProtKB/TrEMBL

A0A8M9QB87

Conserved Domains (1) summary

pfam00233
Location:122 → 350

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase