cyp11a1.1 cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp11a1.1provided by ZNC
Official Full Name: cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010306-1
See related: Ensembl:ENSDARG00000002347 AllianceGenome:ZFIN:ZDB-GENE-010306-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb957; P450scc; cyp11a1; wu:fj97d10
Summary: Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity. Acts upstream of or within several processes, including C21-steroid hormone biosynthetic process; determination of heart left/right asymmetry; and positive regulation of microtubule polymerization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including brain; endocrine system; interrenal primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

Location:: chromosome: 25

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (22313602..22335283)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (22222380..22237735)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of cyp11a1 during embryogenesis [Review]
Title: Zebrafish cyp11a1 and hsd3b genes: structure, expression and steroidogenic development during embryogenesis.
The putative promoter of zebrafish cyp11a1, spanning 1.7 kb, was isolated and bioinformatic analysis revealed two conserved FF1 response elements (FREs) that potentially bind Ff1b.
Title: Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b.
cyp11a1 is expressed in the cytoplasm of oocytes, as a maternal transcript, and in yolk syncytial layer during early embryogenesis
Title: Expression of zebrafish cyp11a1 as a maternal transcript and in yolk syncytial layer.

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General gene information

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Markers

fe37g06.x1 (e-PCR)
- UniSTS:196446

scc (e-PCR)
- UniSTS:205512

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol monooxygenase (side-chain-cleaving) activity	IC Inferred by Curator more info	PubMed
enables cholesterol monooxygenase (side-chain-cleaving) activity	IEA Inferred from Electronic Annotation more info
enables cholesterol monooxygenase (side-chain-cleaving) activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within C21-steroid hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of microtubule polymerization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cholesterol side-chain cleavage enzyme, mitochondrial

Names: cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA, polypeptide 1; scc; side-chain cleavage enzyme

NP_694485.2

EC 1.14.15.6

XP_068073526.1

EC 1.14.15.6

XP_068073527.1

EC 1.14.15.6

XP_068073528.1

EC 1.14.15.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152953.2 → NP_694485.2 cholesterol side-chain cleavage enzyme, mitochondrial

See identical proteins and their annotated locations for NP_694485.2

Status: PROVISIONAL

Source sequence(s)

BC054701

UniProtKB/TrEMBL

A0A8M1PBM4, Q7SYJ6

Related

ENSDARP00000025030.6, ENSDART00000024866.10

Conserved Domains (1) summary

pfam00067
Location:66 → 502

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

22313602..22335283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068217427.1 → XP_068073528.1 cholesterol side-chain cleavage enzyme, mitochondrial isoform X1
XM_068217426.1 → XP_068073527.1 cholesterol side-chain cleavage enzyme, mitochondrial isoform X1
XM_068217425.1 → XP_068073526.1 cholesterol side-chain cleavage enzyme, mitochondrial isoform X1