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siah1 siah E3 ubiquitin protein ligase 1 [ Danio rerio (zebrafish) ]

Gene ID: 80955, updated on 2-Nov-2024

Summary

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Official Symbol
siah1provided by ZNC
Official Full Name
siah E3 ubiquitin protein ligase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-010319-31
See related
Ensembl:ENSDARG00000030871 AllianceGenome:ZFIN:ZDB-GENE-010319-31
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Siah1a; zgc:56026; id:ibd2635
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in neuron apoptotic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in germ ring; myotome; nervous system; and optic fissure. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See siah1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (18439332..18472257)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (18450266..18483192)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488222 Neighboring gene nedd4 binding protein 1 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene interleukin 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish. Piedade WP, et al. Front Cell Dev Biol, 2020. PMID 33330480, Free PMC Article
  2. Ubiquitin-mediated proteasome degradation regulates optic fissure fusion. Pereira Piedade W, et al. Biol Open, 2019 Jun 17. PMID 31189662, Free PMC Article
  3. Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development. Kang N, et al. Mol Cells, 2014 May. PMID 24823357, Free PMC Article
  4. Processing of fish Ig heavy chain transcripts: diverse splicing patterns and unusual nonsense mediated decay. Quiniou SM, et al. Dev Comp Immunol, 2011 Sep. PMID 21168434
  5. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Siah1
Names
RING-type E3 ubiquitin transferase SIAH1
seven in absentia 1A
seven in absentia homolog 1
siah-1
NP_955815.1
XP_005159200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199521.2 → NP_955815.1  E3 ubiquitin-protein ligase Siah1

    See identical proteins and their annotated locations for NP_955815.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045870
    UniProtKB/TrEMBL
    A0A0H2UKD5
    Related
    ENSDARP00000043842.6, ENSDART00000043843.7
    Conserved Domains (2) summary
    cd16751
    Location:43 → 82
    RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins
    pfam03145
    Location:86 → 282
    Sina; Seven in absentia protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    18439332..18472257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159143.5 → XP_005159200.1  E3 ubiquitin-protein ligase Siah1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IPD0, A0A8M2B5M1
    Related
    ENSDARP00000137095.1, ENSDART00000165079.2
    Conserved Domains (1) summary
    pfam03145
    Location:134 → 330
    Sina; Seven in absentia protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVG6.2 GenPept UniProtKB/Swiss-Prot:Q7ZVG6

Gene LinkOut

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