pard6gb par-6 family cell polarity regulator gamma b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pard6gbprovided by ZNC
Official Full Name: par-6 family cell polarity regulator gamma bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010319-35
See related: Ensembl:ENSDARG00000036090 AllianceGenome:ZFIN:ZDB-GENE-010319-35
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb182; PARD6G; sb:cb182; id:ibd2873; wu:fc33c12
Summary: Predicted to enable protein kinase C binding activity. Acts upstream of or within several processes, including animal organ development; apical protein localization; and tube morphogenesis. Located in several cellular components, including apical plasma membrane; cleavage furrow; and nucleus. Is expressed in several structures, including EVL; axis; central nervous system; immature eye; and pharyngeal arch. Orthologous to human PARD6G (par-6 family cell polarity regulator gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (25699329..25772843, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (26115106..26188620, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pard6alpha, but not Pard6beta or Pard6gammaa, could partially rescue the pard6gammab(s441) mutant phenotypes. Altogether, these data indicate a previously unappreciated functional diversity and complexity within the vertebrate pard6 gene family.
Title: Regulation of neurocoel morphogenesis by Pard6 gamma b.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cloaca development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cloaca development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: par-6 family cell polarity regulator gamma b

Names: par-6 partitioning defective 6 homolog gamma B; par-6 partitioning defective 6-like protein gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212563.1 → NP_997728.1 par-6 family cell polarity regulator gamma b

See identical proteins and their annotated locations for NP_997728.1

Status: PROVISIONAL

Source sequence(s)

AY391446

UniProtKB/TrEMBL

A0A8M1PHH4, Q6TNS1

Related

ENSDARP00000052392.3, ENSDART00000052393.4

Conserved Domains (2) summary

cd06403
Location:19 → 98

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:157 → 248

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...