Kat5 K(lysine) acetyltransferase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat5provided by MGI
Official Full Name: K(lysine) acetyltransferase 5provided by MGI
Primary source: MGI:MGI:1932051
See related: Ensembl:ENSMUSG00000024926 AllianceGenome:MGI:1932051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PLIP; CPLA2; Tip55; Tip60; Htatip; Htatip1
Summary: Enables chromatin binding activity; histone acetyltransferase activity; and transcription coactivator activity. Involved in several processes, including nervous system development; positive regulation of regulatory T cell differentiation; and sperm DNA condensation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Part of NuA4 histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 21.5), testis adult (RPKM 19.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5653042..5661584, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5603014..5611556, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance.
Title: Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance.
TIP60 is required for tumorigenesis in non-small cell lung cancer.
Title: TIP60 is required for tumorigenesis in non-small cell lung cancer.
The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.
Title: The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.
Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells.
Title: Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells.
Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice.
Title: Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice.
Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation.
Title: Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation.
Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction.
Title: Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction.
Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice.
Title: Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice.
Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes.
Title: Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes.
O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis.
Title: O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI839539 (e-PCR)
- UniSTS:164644

NoName (e-PCR)
- UniSTS:493351

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2A acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H2A acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide 2-hydroxyisobutyryltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide butyryltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide butyryltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide crotonyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide crotonyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-lysine-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair-dependent chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect lipid droplet disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect lipid droplet disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neural tube development	IDA Inferred from Direct Assay more info	PubMed
involved_in neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of aggrephagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aggrephagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein acetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in sperm DNA condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of NuA4 histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Swr1 complex	ISO Inferred from Sequence Orthology more info
part_of Swr1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of piccolo histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of piccolo histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone acetyltransferase KAT5

Names: 60 kDa Tat-interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; Tat-interactive protein-60; histone acetyltransferase HTATIP; lysine acetyltransferase 5; protein 2-hydroxyisobutyryltransferase KAT5; protein acetyltransferase KAT5; protein crotonyltransferase KAT5

NP_001186176.1

EC 2.3.1.48

NP_001186177.1

EC 2.3.1.48

NP_001186178.1

EC 2.3.1.48

NP_001349299.1

EC 2.3.1.48

NP_001349300.1

EC 2.3.1.48

NP_001349301.1

EC 2.3.1.48

NP_848752.1

EC 2.3.1.48

XP_006531923.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199247.1 → NP_001186176.1 histone acetyltransferase KAT5 isoform 2

See identical proteins and their annotated locations for NP_001186176.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter isoform (2, also known as beta), compared to isoform 1.

Source sequence(s)

AF528196, CJ080877, DV648619

Consensus CDS

CCDS89314.1

UniProtKB/TrEMBL

A2VDH4

Related

ENSMUSP00000158391.2, ENSMUST00000236229.2

Conserved Domains (2) summary

PLN00104
Location:43 → 452

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam11717
Location:7 → 65

Tudor-knot; RNA binding activity-knot of a chromodomain
NM_001199248.1 → NP_001186177.1 histone acetyltransferase KAT5 isoform 3

See identical proteins and their annotated locations for NP_001186177.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the 5' coding region, compared to variant 1. It encodes a shorter isoform (3, also known as gamma), compared to isoform 1.

Source sequence(s)

AF528195, AK160077, CJ080877, DV648619

Consensus CDS

CCDS89313.1

UniProtKB/TrEMBL

A0A494BAP7, A2VDH4

Related

ENSMUSP00000158181.2, ENSMUST00000235701.2

Conserved Domains (2) summary

PLN00104
Location:76 → 485

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam11717
Location:40 → 98

Tudor-knot; RNA binding activity-knot of a chromodomain
NM_001199249.1 → NP_001186178.1 histone acetyltransferase KAT5 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the 5' and 3' coding regions, compared to variant 1. It encodes a shorter isoform (4, also known as delta) with a unique C-terminus, compared to isoform 1.

Source sequence(s)

AK143674, CA317697, CJ080877

Related

ENSMUST00000235788.2

Conserved Domains (2) summary

pfam11717
Location:40 → 98

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:200 → 378

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
NM_001362370.1 → NP_001349299.1 histone acetyltransferase KAT5 isoform 5

Status: VALIDATED

Source sequence(s)

AC126029, AF528196, BY269987, DV648619

Related

ENSMUST00000236964.2

Conserved Domains (1) summary

PLN00104
Location:7 → 293

PLN00104; MYST -like histone acetyltransferase; Provisional
NM_001362371.1 → NP_001349300.1 histone acetyltransferase KAT5 isoform 5

Status: VALIDATED

Source sequence(s)

AC126029, DV648619

Conserved Domains (1) summary

PLN00104
Location:7 → 293

PLN00104; MYST -like histone acetyltransferase; Provisional
NM_001362372.1 → NP_001349301.1 histone acetyltransferase KAT5 isoform 6

Status: VALIDATED

Source sequence(s)

AC126029, DV648619

UniProtKB/TrEMBL

A2VDH4

Conserved Domains (2) summary

PLN00104
Location:76 → 537

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam11717
Location:40 → 98

Tudor-knot; RNA binding activity-knot of a chromodomain
NM_178637.2 → NP_848752.1 histone acetyltransferase KAT5 isoform 1

See identical proteins and their annotated locations for NP_848752.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as alpha).

Source sequence(s)

AF528195, CJ080877, DV648619

Consensus CDS

CCDS29472.1

UniProtKB/Swiss-Prot

A0A494B9U8, A1L394, Q3YFI9, Q8CGZ3, Q8CGZ4, Q8CHK4, Q8VIH0

UniProtKB/TrEMBL

A2VDH4, Q3UJQ1

Related

ENSMUSP00000109271.3, ENSMUST00000113641.4

Conserved Domains (2) summary

PLN00104
Location:43 → 504

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam11717
Location:7 → 65

Tudor-knot; RNA binding activity-knot of a chromodomain

RNA

NR_155544.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126029, DV648619

Related

ENSMUST00000236883.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5653042..5661584 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531860.3 → XP_006531923.1 histone acetyltransferase KAT5 isoform X1

See identical proteins and their annotated locations for XP_006531923.1

UniProtKB/TrEMBL

A2VDH4

Conserved Domains (2) summary

PLN00104
Location:227 → 513

PLN00104; MYST -like histone acetyltransferase; Provisional

cd18985
Location:14 → 77

CBD_TIP60_like; chromo barrel domain of human tat-interactive protein 60, and similar proteins