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AKAP17A A-kinase anchoring protein 17A [ Homo sapiens (human) ]

Gene ID: 8227, updated on 4-Jan-2025

Summary

Official Symbol
AKAP17Aprovided by HGNC
Official Full Name
A-kinase anchoring protein 17Aprovided by HGNC
Primary source
HGNC:HGNC:18783
See related
Ensembl:ENSG00000197976 Ensembl:ENSG00000292343 MIM:312095; MIM:465000; AllianceGenome:HGNC:18783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E
Summary
This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in spleen (RPKM 26.3), bone marrow (RPKM 23.0) and 25 other tissues See more
Orthologs
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Genomic context

See AKAP17A in Genome Data Viewer
Location:
X;Y
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1591604..1602520)
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1591604..1602520)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1393022..1403889)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1455997..1466654)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1710497..1721413)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1660497..1671413)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene P2Y receptor family member 8 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:1718443-1718962 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776191-1776692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776693-1777192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:1747612-1748179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrY:1778143-1778642 Neighboring gene long intergenic non-protein coding RNA 2968

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene P2Y receptor family member 8 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:1718443-1718962 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776191-1776692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776693-1777192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:1747612-1748179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrY:1778143-1778642 Neighboring gene long intergenic non-protein coding RNA 2968

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Interactions

General gene information

Clone Names

  • FLJ98315, MGC39904, MGC125365, MGC125366

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell activation PubMed 
involved_in RNA splicing  
involved_in mRNA processing  
involved_in regulation of DNA-templated transcription PubMed 
involved_in regulation of RNA splicing  
involved_in regulation of RNA splicing PubMed 
involved_in signal transduction PubMed 
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol  
is_active_in nuclear speck  
located_in nuclear speck PubMed 
located_in nucleus PubMed 
part_of spliceosomal complex  

General protein information

Preferred Names
A-kinase anchor protein 17A
Names
A kinase (PRKA) anchor protein 17A
B-lymphocyte surface antigen
protein kinase A-anchoring protein 17A
pseudoautosomal gene XE7
splicing factor, arginine/serine-rich 17A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021470.1 RefSeqGene

    Range
    5012..15928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005088.3NP_005079.2  A-kinase anchor protein 17A isoform 1

    See identical proteins and their annotated locations for NP_005079.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC015800, BC016935, BC028151, BM046630, BM713425, M99578
    Consensus CDS
    CCDS14116.1
    UniProtKB/Swiss-Prot
    Q02040, Q02832, Q2TB98, Q5JQ74, Q5JQ76, Q8N6U9
    Related
    ENSP00000324827.3, ENSP00000518597.1, ENST00000313871.9, ENST00000711132.1
    Conserved Domains (3) summary
    cd12264
    Location:143265
    RRM_AKAP17A; RNA recognition motif found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins
    cd16269
    Location:424433
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:345433
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_027383.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate coding exon that results in a frameshift and prematurely truncated open reading frame. The transcript is predicted to be subject to nonsense-mediated decay (NMD) and thus the predicted protein product is not annotated on the record.
    Source sequence(s)
    AL683807, BC015800, BC016935, BC028151, BC110497, L03426, M99578
    Related
    ENST00000474361.6, ENST00000711186.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    1591604..1602520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    1591604..1602520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    1393022..1403889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    1455997..1466654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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