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Mybph myosin binding protein H [ Rattus norvegicus (Norway rat) ]

Gene ID: 83708, updated on 10-Jul-2024

Summary

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Official Symbol
Mybphprovided by RGD
Official Full Name
myosin binding protein Hprovided by RGD
Primary source
RGD:620287
See related
EnsemblRapid:ENSRNOG00000003336 AllianceGenome:RGD:620287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cell adhesion. Predicted to be located in myosin filament. Used to study hypertension. Orthologous to human MYBPH (myosin binding protein H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 536.7), Brain (RPKM 92.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Mybph in Genome Data Viewer
Location:
13q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48205162..48212928)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45653156..45660893)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51034228..51041903)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552406 Neighboring gene chitinase 3 like 1 Neighboring gene adenosine A1 receptor Neighboring gene uncharacterized LOC120096189 Neighboring gene myogenin Neighboring gene PTPRF interacting protein alpha 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model. Zhu T, et al. Exp Cell Res, 2017 Oct 1. PMID 28800959
  2. Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction. Mouton J, et al. Exp Cell Res, 2015 Feb 15. PMID 25449695
  3. Nucleotide and deduced amino acid sequences of rat myosin binding protein H (MyBP-H). Jung J, et al. Arch Pharm Res, 1998 Dec. PMID 9868543
  4. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDGF-induced VSMC migration was inhibited by adenovirus-mediated expression of MYBPH whereas it was enhanced by small interfering RNA knockdown of MYBPH.
    Title: MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model.
  2. This study provides evidence for a potential role of MyBPH in hypertrophic cardiomyopathy.
    Title: Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-binding protein H
Names
H-protein
myBP-H
norvegicus myosin binding protein H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031813.2 → NP_114001.2  myosin-binding protein H

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICA9, G3V6F1, Q6P6V8
    Related
    ENSRNOP00000004528.4, ENSRNOT00000004528.8
    Conserved Domains (5) summary
    PRK12270
    Location:5 → 83
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
    cd00063
    Location:78 → 164
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:389 → 478
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:392 → 395
    Ig; Ig strand A [structural motif]
    cd05748
    Location:190 → 270
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    48205162..48212928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249888.5 → XP_006249950.1  myosin-binding protein H isoform X1

    UniProtKB/TrEMBL
    Q6P6V8
    Related
    ENSRNOP00000111832.1, ENSRNOT00000151198.1
    Conserved Domains (5) summary
    cd00096
    Location:408 → 472
    Ig; Immunoglobulin domain
    cd05748
    Location:198 → 270
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00410
    Location:189 → 270
    IG_like; Immunoglobulin like
    cd00063
    Location:78 → 164
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:389 → 478
    I-set; Immunoglobulin I-set domain

  2. XM_006249889.5 → XP_006249951.1  myosin-binding protein H isoform X2

    See identical proteins and their annotated locations for XP_006249951.1

    UniProtKB/TrEMBL
    A6ICA9, G3V6F1, Q6P6V8
    Conserved Domains (5) summary
    PRK12270
    Location:5 → 83
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
    cd00063
    Location:78 → 164
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:389 → 478
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:392 → 395
    Ig; Ig strand A [structural motif]
    cd05748
    Location:190 → 270
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

RNA

  1. XR_358910.5 RNA Sequence

  2. XR_358909.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88599.1 GenPept UniProtKB/Swiss-Prot:O88599

Gene LinkOut

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