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cry2 cryptochrome circadian regulator 2 [ Danio rerio (zebrafish) ]

Gene ID: 83774, updated on 28-Oct-2024

Summary

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Official Symbol
cry2provided by ZNC
Official Full Name
cryptochrome circadian regulator 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-010426-6
See related
Ensembl:ENSDARG00000102403 AllianceGenome:ZFIN:ZDB-GENE-010426-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cry3; zcry3; fe16d07; wu:fe16d07
Summary
Predicted to enable DNA binding activity and FAD binding activity. Acts upstream of or within negative regulation of DNA-templated transcription; response to light stimulus; and response to temperature stimulus. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; eye; inner ear; liver; and pleuroperitoneal region. Orthologous to human CRY2 (cryptochrome circadian regulator 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See cry2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (13847458..13871118, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (13751058..13774755, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene cytoskeleton associated protein 5 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1a Neighboring gene zgc:101566 Neighboring gene carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of a new cryptochrome class. Structure, function, and evolution. Brudler R, et al. Mol Cell, 2003 Jan. PMID 12535521
  2. Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases. Cermakian N, et al. Curr Biol, 2002 May 14. PMID 12015122
  3. Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors. Balay SD, et al. Gene Expr Patterns, 2020 Jan. PMID 32088341
  4. Effects of cryptochrome-modulating compounds on circadian behavioural rhythms in zebrafish. Iida M, et al. J Biochem, 2022 May 11. PMID 34528676
  5. Midnight/midday-synchronized expression of cryptochrome genes in the eyes of three teleost species, zebrafish, goldfish, and medaka. Nakagawa M, et al. Zoological Lett, 2022 Jun 7. PMID 35672786, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors.
    Title: Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors.
  2. zCRY1a, and zCRY2a function in synchronizing cellular clocks
    Title: The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish.
  3. Data indicate that magnetic receptor magnetoreceptor (MagR) and cryptochrome cry2 exist as a single copy gene, whereas cry1 exists as multiple gene duplicates (cry1aa, cry1ab, cry1ba and cry1bb).
    Title: Identification of zebrafish magnetoreceptor and cryptochrome homologs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within response to light stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to temperature stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
  

General protein information

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Preferred Names
cryptochrome-2
Names
cryptochrome 3
cryptochrome circadian clock 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131786.2 → NP_571861.2  cryptochrome-2

    See identical proteins and their annotated locations for NP_571861.2

    Status: PROVISIONAL

    Source sequence(s)
    BC046088
    UniProtKB/TrEMBL
    A0A8M1PCY7, Q7ZU53
    Related
    ENSDARP00000134736.1, ENSDART00000160866.2
    Conserved Domains (3) summary
    COG0415
    Location:5 → 491
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam00875
    Location:5 → 169
    DNA_photolyase; DNA photolyase
    pfam03441
    Location:213 → 486
    FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    13847458..13871118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials