U.S. flag

An official website of the United States government

CAVIN2 caveolae associated protein 2 [ Homo sapiens (human) ]

Gene ID: 8436, updated on 4-Jan-2025

Summary

Official Symbol
CAVIN2provided by HGNC
Official Full Name
caveolae associated protein 2provided by HGNC
Primary source
HGNC:HGNC:10690
See related
Ensembl:ENSG00000168497 MIM:606728; AllianceGenome:HGNC:10690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR; SDPR; PS-p68; cavin-2
Summary
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Expression
Broad expression in fat (RPKM 116.9), lung (RPKM 67.0) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CAVIN2 in Genome Data Viewer
Location:
2q32.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (191834310..191847088, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (192322523..192335302, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192699036..192711814, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373812 Neighboring gene hCG2045843 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:192690474-192691049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:192711519-192712027 Neighboring gene CAVIN2 and TMEFF2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6341 Neighboring gene Sharpr-MPRA regulatory region 2977 Neighboring gene DNAJB1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 5853 Neighboring gene transmembrane protein with EGF like and two follistatin like domains 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192867249-192867501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16884 Neighboring gene NANOG hESC enhancer GRCh37_chr2:192976090-192976700 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:192994983-192995675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:192995676-192996367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:193059605-193060180

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylserine binding PubMed 
enables phospholipid binding PubMed 
enables protein binding PubMed 
enables protein kinase C binding  
Component Evidence Code Pubs
is_active_in caveola  
located_in caveola PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol PubMed 
located_in membrane raft PubMed 
located_in nucleoplasm  
located_in plasma membrane  

General protein information

Preferred Names
caveolae-associated protein 2
Names
phosphatidylserine-binding protein
serum deprivation response
serum deprivation-response protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004657.6NP_004648.1  caveolae-associated protein 2

    See identical proteins and their annotated locations for NP_004648.1

    Status: REVIEWED

    Source sequence(s)
    BC016475, BM971534, BQ025694, DA561006, R55388
    Consensus CDS
    CCDS2313.1
    UniProtKB/Swiss-Prot
    O95810
    UniProtKB/TrEMBL
    A8K2W3
    Related
    ENSP00000305675.4, ENST00000304141.5
    Conserved Domains (1) summary
    pfam15237
    Location:53294
    PTRF_SDPR; PTRF/SDPR family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    191834310..191847088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    192322523..192335302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.