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Tle3 TLE family member 3, transcriptional corepressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 84424, updated on 2-Nov-2024

Summary

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Official Symbol
Tle3provided by RGD
Official Full Name
TLE family member 3, transcriptional corepressorprovided by RGD
Primary source
RGD:620292
See related
EnsemblRapid:ENSRNOG00000013013 AllianceGenome:RGD:620292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Esp3
Summary
Predicted to enable transcription corepressor activity. Involved in regulation of DNA-templated transcription. Located in nucleus. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 84.5), Adrenal (RPKM 70.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tle3 in Genome Data Viewer
Location:
8q24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (70753182..70799080)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (61857791..61903505)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (66296509..66342186)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693113 Neighboring gene uncharacterized LOC134480065 Neighboring gene uncharacterized LOC102551666 Neighboring gene uncharacterized LOC102552398 Neighboring gene ribosomal protein lateral stalk subunit P1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. rTLE3, a newly identified transducin-like enhancer of split, is induced by depolarization in brain. Feldman JD, et al. J Neurochem, 2000 May. PMID 10800926
  2. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Villanueva CJ, et al. Cell Metab, 2013 Mar 5. PMID 23473036, Free PMC Article
  3. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. Wang JC, et al. J Biol Chem, 2000 Jun 16. PMID 10748198
  4. Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. van Tienen LM, et al. Elife, 2017 Mar 15. PMID 28296634, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
  
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 3
Names
rTLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 3 homolog of Drosophila
transducin-like enhancer of split 3, E(spl) homolog
transducin-like enhancer of split 3, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053400.2 → NP_445852.1  transducin-like enhancer protein 3

    See identical proteins and their annotated locations for NP_445852.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q9JIT3
    UniProtKB/TrEMBL
    A0A8I5ZNN2, A6J560
    Related
    ENSRNOP00000018467.7, ENSRNOT00000018467.8
    Conserved Domains (4) summary
    cd00200
    Location:476 → 761
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:251 → 464
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:481 → 520
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    70753182..70799080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766347.4 → XP_008764569.1  transducin-like enhancer protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008764569.1

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Related
    ENSRNOP00000079710.2, ENSRNOT00000108424.2
    Conserved Domains (4) summary
    cd00200
    Location:494 → 779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:261 → 482
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:499 → 538
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_006243214.5 → XP_006243276.1  transducin-like enhancer protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    COG2319
    Location:483 → 775
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:489 → 774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:494 → 533
    7WD40; WD40 repeat [structural motif]

  3. XM_006243213.5 → XP_006243275.1  transducin-like enhancer protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Related
    ENSRNOP00000109823.1, ENSRNOT00000164911.1
    Conserved Domains (4) summary
    COG2319
    Location:485 → 777
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:491 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]

  4. XM_006243215.5 → XP_006243277.1  transducin-like enhancer protein 3 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    COG2319
    Location:480 → 772
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:486 → 771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:491 → 530
    7WD40; WD40 repeat [structural motif]

  5. XM_006243212.5 → XP_006243274.1  transducin-like enhancer protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    COG2319
    Location:487 → 779
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:493 → 778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:498 → 537
    7WD40; WD40 repeat [structural motif]

  6. XM_063266230.1 → XP_063122300.1  transducin-like enhancer protein 3 isoform X4

  7. XM_063266231.1 → XP_063122301.1  transducin-like enhancer protein 3 isoform X7

  8. XM_006243216.5 → XP_006243278.1  transducin-like enhancer protein 3 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    cd00200
    Location:484 → 769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:251 → 472
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:489 → 528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  9. XM_006243219.5 → XP_006243281.1  transducin-like enhancer protein 3 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    cd00200
    Location:479 → 764
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:251 → 467
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:484 → 523
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  10. XM_006243218.5 → XP_006243280.1  transducin-like enhancer protein 3 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    cd00200
    Location:481 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:251 → 469
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  11. XM_006243217.5 → XP_006243279.1  transducin-like enhancer protein 3 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    COG2319
    Location:477 → 769
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:483 → 768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:488 → 527
    7WD40; WD40 repeat [structural motif]

  12. XM_006243220.5 → XP_006243282.1  transducin-like enhancer protein 3 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    COG2319
    Location:472 → 764
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:478 → 763
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:483 → 522
    7WD40; WD40 repeat [structural motif]

  13. XM_006243221.5 → XP_006243283.1  transducin-like enhancer protein 3 isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    cd00200
    Location:475 → 760
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:250 → 463
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:480 → 519
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  14. XM_063266234.1 → XP_063122304.1  transducin-like enhancer protein 3 isoform X12

  15. XM_006243211.5 → XP_006243273.1  transducin-like enhancer protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006243273.1

    UniProtKB/TrEMBL
    A0A8I5ZNN2
    Conserved Domains (4) summary
    cd00200
    Location:494 → 779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:261 → 482
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:499 → 538
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  16. XM_063266232.1 → XP_063122302.1  transducin-like enhancer protein 3 isoform X10

  17. XM_063266233.1 → XP_063122303.1  transducin-like enhancer protein 3 isoform X11

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIT3.1 GenPept UniProtKB/Swiss-Prot:Q9JIT3

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