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Ccs copper chaperone for superoxide dismutase [ Rattus norvegicus (Norway rat) ]

Gene ID: 84485, updated on 2-Nov-2024

Summary

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Official Symbol
Ccsprovided by RGD
Official Full Name
copper chaperone for superoxide dismutaseprovided by RGD
Primary source
RGD:620403
See related
EnsemblRapid:ENSRNOG00000047816 AllianceGenome:RGD:620403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables enzyme binding activity. Predicted to be involved in removal of superoxide radicals. Predicted to act upstream of or within positive regulation of oxidoreductase activity. Predicted to be located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 294.2), Kidney (RPKM 212.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccs in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211543192..211564354, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202113792..202134931, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220075251..220096319, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4B Neighboring gene proteasome subunit alpha type-3-like Neighboring gene RNA binding motif protein 4 Neighboring gene coiled-coil domain containing 87 Neighboring gene cathepsin F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD. Williams JR, et al. Neurobiol Dis, 2016 May. PMID 26826269, Free PMC Article
  2. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. Angeletti B, et al. J Biol Chem, 2005 May 6. PMID 15722349
  3. Copper modulates the degradation of copper chaperone for Cu,Zn superoxide dismutase by the 26 S proteosome. Bertinato J, et al. J Biol Chem, 2003 Sep 12. PMID 12832419
  4. Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats. Bertinato J, et al. J Nutr, 2003 Jan. PMID 12514262
  5. Molecular cloning and characterization of a copper chaperone for copper/zinc superoxide dismutase from the rat. Hiromura M, et al. Biochem Biophys Res Commun, 2000 Aug 28. PMID 10964676

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Copper modulates the degradation of this protein, which prioritizes the utilization of copper when it is scarce.
    Title: Copper modulates the degradation of copper chaperone for Cu,Zn superoxide dismutase by the 26 S proteosome.
  2. Associated with copper deficiency were higher levels of Ccs in erythrocytes.
    Title: Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice.
  3. Beta-site amyloid precursor (APP) cleaving enzyme BACE1 expression reduces the activity of superoxide dismutase (SOD1) in cells consistent with direct competition for available CCS, as overexpression of CCS restores SOD1 activity.
    Title: BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase copper chaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide dismutase copper chaperone activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
  
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
copper chaperone for superoxide dismutase
Names
superoxide dismutase copper chaperone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053425.1 → NP_445877.1  copper chaperone for superoxide dismutase

    See identical proteins and their annotated locations for NP_445877.1

    Status: PROVISIONAL

    Source sequence(s)
    AF255305
    UniProtKB/Swiss-Prot
    B0BMW1, Q9JK72
    UniProtKB/TrEMBL
    A0A0G2JSZ9, A6HYZ6
    Related
    ENSRNOP00000065189.2, ENSRNOT00000073983.4
    Conserved Domains (3) summary
    PLN02957
    Location:13 → 253
    PLN02957; copper, zinc superoxide dismutase
    cd00305
    Location:89 → 227
    Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
    cd00371
    Location:15 → 73
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    211543192..211564354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092800.2 → XP_038948728.1  copper chaperone for superoxide dismutase isoform X1

    Conserved Domains (1) summary
    PLN02957
    Location:13 → 148
    PLN02957; copper, zinc superoxide dismutase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JK72.1 GenPept UniProtKB/Swiss-Prot:Q9JK72

Gene LinkOut

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